Uwakwe Laura N, Cardwell Leah A, Dothard Emily H, Baroudi Bernice I, McMichael Amy J
J Drugs Dermatol. 2018 Apr 1;17(4):397-400.
The association of frontal fibrosing alopecia (FFA) and lichen planus pigmentosus (LPPigm) is rare. Prior reports suggest that FFA and LPPigm are on the same spectrum of disease, and a diagnosis of LPPigm may predict the future development of FFA. We aim to further characterize the association between FFA and LPPigm by reviewing the clinical cases of seven African American women. Seven patients with FFA were diagnosed clinically by recession of frontotemporal hairline and confirmed by histopathologic examination showing lymphocyte-mediated cicatricial alopecia. LPPigm was diagnosed by clinical evaluation alone based on the characteristic morphology, color, and distribution of the lesions. It is difficult to distinguish whether halted progression of FFA was due to the success of the treatment regimen or spontaneous stabilization of disease over time. Our case series supports the theory that FFA and LPPigm likely exist on the same spectrum of disease. Our observations demonstrate a likely positive correlation between FFA and LPPigm.
J Drugs Dermatol. 2018;17(4):397-400.
.额部纤维性秃发(FFA)与色素性扁平苔藓(LPPigm)的关联较为罕见。既往报道提示FFA和LPPigm属于同一疾病谱,LPPigm的诊断可能预示FFA的未来发展。我们旨在通过回顾7名非裔美国女性的临床病例,进一步明确FFA与LPPigm之间的关联。7例FFA患者通过额颞部发际线后移进行临床诊断,并经组织病理学检查证实为淋巴细胞介导的瘢痕性秃发。LPPigm仅通过基于病变特征性形态、颜色和分布的临床评估进行诊断。很难区分FFA进展停止是由于治疗方案的成功还是疾病随时间自发稳定。我们的病例系列支持FFA和LPPigm可能存在于同一疾病谱的理论。我们的观察结果表明FFA与LPPigm之间可能存在正相关。
《皮肤药物学杂志》。2018年;17(4):397 - 400。