Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, No. 2, Chongwenmennei Street, Dongcheng, Beijing, 100730, China.
Department of Colorectal and Anal Surgery, Beijing Coloproctological Hospital (Beijing Erlonglu Hospital), Beijing, 100032, China.
Int J Surg. 2018 May;53:193-200. doi: 10.1016/j.ijsu.2018.03.050. Epub 2018 Mar 28.
Recent studies have demonstrated that the over-expression of Nanog contributes to the progression of various malignant tumors. However, the clinicopathological and prognostic role of Nanog in gastrointestinal luminal cancer remains controversial. Therefore, we conducted a meta-analysis to assess the role of Nanog in gastrointestinal luminal cancer.
An electronic search for relevant literature was performed in PubMed, Cochrane Library, Web of Science, and EMBASE databases. The relationships between Nanog expression and clinicopathological features and survival outcomes were analyzed. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated by STATA14.2 and RevMan 5.3 software.
A total of 9 studies with 1526 patients were included in this meta-analysis. The positive expression of Nanog was related to gender, depth of infiltration, differentiation, and TNM stage; however, it was not associated with age, tumor size, or lymph node metastasis. Moreover, positive Nanog expression was correlated with a poor overall survival (OS) and poor disease-free survival (DFS) in gastrointestinal luminal cancer.
The pooled results suggested that Nanog expression was associated with gender, depth of infiltration, differentiation, and TNM stage, and Nanog may be a potential biomarker to predict the prognosis of gastrointestinal luminal cancer.
最近的研究表明，Nanog 的过度表达有助于各种恶性肿瘤的进展。然而，Nanog 在胃肠道腔癌中的临床病理和预后作用仍存在争议。因此，我们进行了一项荟萃分析，以评估 Nanog 在胃肠道腔癌中的作用。
在 PubMed、Cochrane Library、Web of Science 和 EMBASE 数据库中进行了相关文献的电子检索。分析了 Nanog 表达与临床病理特征和生存结局的关系。使用 STATA14.2 和 RevMan 5.3 软件计算合并的优势比 (OR) 和风险比 (HR) 及其 95%置信区间 (CI)。
这项荟萃分析共纳入了 9 项研究，共计 1526 例患者。Nanog 的阳性表达与性别、浸润深度、分化和 TNM 分期有关；然而，与年龄、肿瘤大小或淋巴结转移无关。此外，Nanog 阳性表达与胃肠道腔癌的总生存期 (OS) 和无病生存期 (DFS) 不良相关。
汇总结果表明，Nanog 表达与性别、浸润深度、分化和 TNM 分期有关，Nanog 可能是预测胃肠道腔癌预后的潜在生物标志物。
