[Genetic determinants of antibiotic resistance in bacteria of the genus Salmonella].

Distribution of genetic determinants of resistance to streptomycin, kanamycin, chloramphenicol, tetracycline, sulfanilamides and trimethoprim in strains of Salmonella isolated from studied. The majority of the resistant strains carried the genes of aminoglycoside-3"-phosphotransferase, type I aminoglycoside-3'-phosphotransferase, type I chloramphenicol acetyltransferase and type II dihydropteroate synthetase. Tetracycline resistance in the strains was often due to the class B tetracycline resistance genetic determinants. It was suggested that the resistance mechanisms controlled by these genes provided higher levels of resistance to the above drugs in Salmonella as compared to the other mechanisms. Plasmid resistance genes were detected in more than 90 per cent of the clinical strains and in 35 per cent of the sporadic strains of S. typhimurium. The antibiotic resistance of the Salmonella strains of other serovars was not as a rule controlled by the plasmid genes.