尼氯硝唑，一种具有多种（再）用途的药物。
Niclosamide, a Drug with Many (Re)purposes.
机构信息
Cardiff School of Pharmacy and Pharmaceutical Sciences, College of Biomedical and Life Sciences, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK.
出版信息
ChemMedChem. 2018 Jun 6;13(11):1088-1091. doi: 10.1002/cmdc.201800100. Epub 2018 May 8.
Abstract
Niclosamide is an anthelmintic drug that has been used for over 50 years mainly to treat tapeworm infections. However, with the increase in drug repurposing initiatives, niclosamide has emerged as a true hit in many screens against various diseases. Indeed, from being an anthelmintic drug, it has now shown potential in treating Parkinson's disease, diabetes, viral and microbial infections, as well as various cancers. Such diverse pharmacological activities are a result of niclosamide's ability to uncouple mitochondrial phosphorylation and modulate a selection of signaling pathways, such as Wnt/β-catenin, mTOR and JAK/STAT3, which are implicated in many diseases. In this highlight, we discuss the plethora of diseases that niclosamide has shown promise in treating.
摘要
尼氯硝唑是一种驱虫药，主要用于治疗绦虫感染，已使用超过 50 年。然而，随着药物再利用计划的增加，尼氯硝唑在许多针对各种疾病的筛选中崭露头角。事实上，从驱虫药到现在，它已经显示出治疗帕金森病、糖尿病、病毒和微生物感染以及各种癌症的潜力。这种多样化的药理活性是由于尼氯硝唑能够解偶联线粒体磷酸化并调节一系列信号通路，如 Wnt/β-catenin、mTOR 和 JAK/STAT3，这些信号通路与许多疾病有关。在这篇重点介绍中，我们讨论了尼氯硝唑在治疗多种疾病方面的应用前景。
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