Enterocyte K ion permeability and fluid secretion: missing the correct channel or missing the point?
作者信息
Lucas Michael L
机构信息
School of Life Sciences, University of Glasgow, Room 311, West Medical Building, Glasgow, G12 9PW, UK.
出版信息
J Physiol. 2018 Jun;596(12):2463-2464. doi: 10.1113/JP276102. Epub 2018 Apr 25.
Abstract
摘要
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本文引用的文献
1
K TASK-2 and KCNQ1-KCNE3 K channels are major players contributing to intestinal anion and fluid secretion.K TASK-2 和 KCNQ1-KCNE3 K 通道是促进肠道阴离子和液体分泌的主要参与者。
J Physiol. 2018 Feb 1;596(3):393-407. doi: 10.1113/JP275178. Epub 2017 Dec 18.
2
Lack of Restoration in Vivo by K-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge.热稳定型大肠菌素（STa）攻击后，通过 K 通道调节剂对回肠液体吸收的体内修复缺失。
J Trop Med. 2011;2011:853686. doi: 10.1155/2011/853686. Epub 2011 Jun 12.
3
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.β亚基 KCNE3 钾通道的破坏揭示了其在肠道和气管 Cl-转运中的重要作用。
J Biol Chem. 2010 Mar 5;285(10):7165-75. doi: 10.1074/jbc.M109.047829. Epub 2010 Jan 5.
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Escherichia coli heat stable (STa) enterotoxin and the upper small intestine: lack of evidence in vivo for net fluid secretion.大肠杆菌热稳定（STa）肠毒素与小肠上段：体内缺乏净液体分泌的证据
J Membr Biol. 2005 Jul;206(1):29-42. doi: 10.1007/s00232-005-0771-6.
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Amendments to the theory underlying Ussing chamber data of chloride ion secretion after bacterial enterotoxin exposure.细菌肠毒素暴露后氯离子分泌的乌斯室数据所依据理论的修正。
J Theor Biol. 2005 May 7;234(1):21-37. doi: 10.1016/j.jtbi.2004.11.005. Epub 2004 Dec 28.
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The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.抗真菌抗生素克霉唑通过阻断不同的基底外侧钾离子通道来抑制人肠道T84细胞的氯离子分泌。在完整的兔结肠和霍乱小鼠体内模型中证实了其疗效。
J Clin Invest. 1997 Dec 15;100(12):3111-20. doi: 10.1172/JCI119866.
7
The enteric nervous system participates in the secretory response to the heat stable enterotoxins of Escherichia coli in rats and cats.肠神经系统参与大鼠和猫对大肠杆菌热稳定肠毒素的分泌反应。
Neuroscience. 1985 Feb;14(2):673-81. doi: 10.1016/0306-4522(85)90318-5.
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