GPCR 遗传易感性：行动呼吁。

Genetic Vulnerability of GPCRs: A Call to Action.

机构信息

Departments of Molecular Pharmacology and Physiology, and Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

出版信息

Trends Biochem Sci. 2018 Apr;43(4):227-229. doi: 10.1016/j.tibs.2018.02.006.

DOI:10.1016/j.tibs.2018.02.006

PMID:29605062

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6092946/

Abstract

G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The 'one-drug-fits-all' approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be undertaken for rational, personalized, and economically sound prescribing practices.

摘要

G 蛋白偶联受体（GPCRs）是许多药物的靶点，但个体间的反应存在差异。“一种药物适合所有人”的方法受到挑战，因为有证据表明 GPCR 存在多种人类遗传变异。为了实现合理、个性化和经济合理的处方实践，必须对 GPCR 变异体进行鉴定和特征描述。