Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson University Hospital, Medical Education Building, Room 478, One Robert Wood Johnson Place, New Brunswick, NJ 08901, USA.
Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson University Hospital, Medical Education Building, Room 466, 1 Robert Wood Johnson Place, New Brunswick, NJ 08901, USA.
Clin Liver Dis. 2018 May;22(2):375-388. doi: 10.1016/j.cld.2018.01.010. Epub 2018 Feb 8.
There is a strong imperative to develop valid and accurate prognostic modeling for acute liver failure (ALF). Despite the numerous clinical models that have been proposed thus far and the use of some such models, that is, King's College Criteria and Model for End-Stage Liver Disease, in clinical practice to aid decision-making, there is a significant need for improvement for determining patients' clinical course, survival, and requirement for liver transplantation. Future prognostic models shall need a stronger statistical foundation and accountability for time and variability in the clinical course of ALF and be applied for pretransplant and posttransplant outcomes.
强烈需要为急性肝衰竭（ALF）开发有效且准确的预后模型。尽管迄今为止已经提出了许多临床模型，并且在临床实践中使用了一些此类模型，例如 King 学院标准和终末期肝病模型，以辅助决策，但仍需要显著改进以确定患者的临床病程、生存和肝移植需求。未来的预后模型需要更强的统计学基础，并对 ALF 临床病程中的时间和变异性负责，并应用于移植前和移植后的结果。
