Boston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, Massachusetts; Bryant University Physician Assistant Program, Smithfield, Rhode Island.
Boston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, Massachusetts; Division of Adolescent and Young Adult Medicine, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan.
Fertil Steril. 2018 Apr;109(4):685-690. doi: 10.1016/j.fertnstert.2017.12.016. Epub 2018 Mar 28.
To determine the prevalence and experience of migraines in adolescents with surgically confirmed endometriosis compared with those without endometriosis.
Cross-sectional study conducted within The Women's Health Study: From Adolescence to Adulthood-an ongoing longitudinal cohort.
Boston Center for Endometriosis.
PATIENT(S): Adolescent females enrolled November 2012 through November 2016. The case group included adolescents surgically diagnosed with endometriosis. The control group included adolescents without endometriosis, recruited from the local community and clinics.
INTERVENTION(S): Not available.
MAIN OUTCOME MEASURE(S): An extensive online health questionnaire regarding medical history, lifestyle, medication use, anthropometrics, and symptom experience and treatments. Migraine diagnosis was self-reported. Migraine pain and noncyclic pelvic pain severity were rated using an 11-point numerical rating scale. Cyclic pelvic pain was categorized.
RESULT(S): Adolescents with endometriosis were more likely to experience migraines (69.3%) than those without endometriosis (30.7%) (multivariable odds ratio = 4.77, 95% confidence interval 2.53, 9.02). For each 1-point increase in the migraine numerical rating scale, the odds of endometriosis increased by 22% (multivariable odds ratio = 1.22, 95% confidence interval 1.03, 1.44; P = .02). Among those with endometriosis, age of menarche was associated inversely with the odds of migraines. Participants with endometriosis and migraines have more dysmenorrhea than those without migraines.
CONCLUSION(S): Adolescents with endometriosis are more likely to experience migraines than adolescents without endometriosis. A linear relationship exists between migraine pain severity and the odds of endometriosis, suggesting heightened pain sensitivity for adolescents with endometriosis. Due to the strong correlation, patients who present with either condition should be screened for comorbidity to maximize the benefits of care.
与没有子宫内膜异位症的青少年相比，确定经手术证实患有子宫内膜异位症的青少年偏头痛的患病率和发病经历。
在正在进行的纵向队列研究《妇女健康研究：从青春期到成年期》中进行的横断面研究。
波士顿子宫内膜异位症中心。
2012 年 11 月至 2016 年 11 月期间入组的青春期女性。病例组包括经手术诊断为子宫内膜异位症的青少年。对照组包括来自当地社区和诊所的无子宫内膜异位症的青少年。
不适用。
一份详细的在线健康问卷，内容包括病史、生活方式、药物使用、人体测量学以及症状发生和治疗情况。偏头痛的诊断为自我报告。偏头痛疼痛和非周期性盆腔疼痛的严重程度使用 11 点数字评分量表进行评估。周期性盆腔疼痛进行分类。
患有子宫内膜异位症的青少年更有可能出现偏头痛（69.3%），而没有子宫内膜异位症的青少年则为 30.7%（多变量优势比=4.77，95%置信区间 2.539.02）。偏头痛数字评分量表每增加 1 分，患子宫内膜异位症的几率增加 22%（多变量优势比=1.22，95%置信区间 1.031.44；P=0.02）。在患有子宫内膜异位症的患者中，初潮年龄与偏头痛的发病几率呈负相关。患有子宫内膜异位症和偏头痛的患者比没有偏头痛的患者痛经更严重。
患有子宫内膜异位症的青少年比没有子宫内膜异位症的青少年更易出现偏头痛。偏头痛疼痛的严重程度与子宫内膜异位症的发病几率之间存在线性关系，这表明子宫内膜异位症患者的疼痛敏感性更高。由于两者之间存在很强的相关性，因此出现任何一种病症的患者都应进行合并症筛查，以最大程度地提高护理效益。
