多粘菌素类似物的构效关系研究。
Study of the structure-activity relationship of polymyxin analogues.
作者信息
Kinoshita Yuhei, Yakushiji Fumika, Matsui Hidehito, Hanaki Hideaki, Ichikawa Satoshi
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
出版信息
Bioorg Med Chem Lett. 2018 Sep 1;28(16):2713-2716. doi: 10.1016/j.bmcl.2018.03.028. Epub 2018 Mar 22.
PMID:29606572
Abstract
A structure-activity relationship study on three classes of polymyxin analogues focusing on hydrophobicity was conducted.
摘要
开展了一项针对三类多粘菌素类似物的构效关系研究，重点关注疏水性。
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