来自刺叶琴木（Citharexylum spinosum L.）的杜兰托苷I的合成类似物及其细胞毒性活性。
Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity.
作者信息
Apisornopas Jutamas, Silalai Patamawadee, Kasemsuk Teerapich, Athipornchai Anan, Sirion Uthaiwan, Suksen Kanoknetr, Piyachaturawat Pawinee, Suksamrarn Apichart, Saeeng Rungnapha
机构信息
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand.
Department of Chemistry, Faculty of Science and Technology, Rambhai Barni Rajabhat University, Chanthaburi 22000, Thailand.
出版信息
Bioorg Med Chem Lett. 2018 May 15;28(9):1558-1561. doi: 10.1016/j.bmcl.2018.03.068. Epub 2018 Mar 27.
New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position and subsequent screening for comparative cytotoxicity against several cancer cell lines. Addition of alkylsilane to durantoside I and removal of cinnamate group were most effective in improving cytotoxicity.
从刺桐（Citharexylum spinosum）干燥的花和叶中提取的杜兰糖苷I合成了新的环烯醚萜苷衍生物，通过硅烷化或乙酰化对糖部分进行各种修饰和/或去除C-7位的肉桂酸酯基团，随后筛选其对几种癌细胞系的比较细胞毒性。向杜兰糖苷I中添加烷基硅烷和去除肉桂酸酯基团对提高细胞毒性最为有效。
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