载脂蛋白 E 携带者与非载脂蛋白 E 携带者在神经认知测试上的差异：詹森效应？
Differences Between APOE Carriers and Non-APOE Carriers on Neurocognitive Tests: Jensen Effects?
机构信息
1 National Research Center for Dementia, Chosun University, Gwangju, Republic of Korea.
2 Work and Organizational Psychology, University of Amsterdam, Amsterdam, the Netherlands.
出版信息
Am J Alzheimers Dis Other Demen. 2018 Sep;33(6):353-361. doi: 10.1177/1533317518765895. Epub 2018 Apr 1.
BACKGROUND
Being a carrier of the apolipoprotein E (APOE) ε4 allele is a clear risk factor for development of Alzheimer's disease (AD). On some neurocognitive tests, there are smaller differences between carriers and noncarriers, while other tests show larger differences.
AIMS
We explore whether the size of the difference between carriers and noncarriers is a function of how well the tests measure general intelligence, so whether there are Jensen effects.
METHODS
We used the method of correlated vectors on 441 Korean older adults at risk for AD and 44 with AD.
RESULTS
Correlations between APOE carriership and test scores ranged from -.05 to .11 (normal), and -.23 to .54 (AD). The differences between carriers and noncarriers were Jensen effects: r = .31 and r = .54, respectively.
CONCLUSION
A composite neurocognitive score may show a clearer contrast between APOE carriers and noncarriers than a large number of scores of single neurocognitive tests.
背景
载脂蛋白 E（APOE）ε4 等位基因的携带者是阿尔茨海默病（AD）发展的明确危险因素。在一些神经认知测试中，携带者和非携带者之间的差异较小，而其他测试则显示出较大的差异。
目的
我们探讨了携带者和非携带者之间的差异大小是否与测试测量一般智力的程度有关，即是否存在詹森效应。
方法
我们使用相关向量法对 441 名有 AD 风险的韩国老年人和 44 名 AD 患者进行了研究。
结果
APOE 携带状态与测试分数之间的相关性范围为 -.05 至.11（正常）和 -.23 至.54（AD）。携带者和非携带者之间的差异是詹森效应：r =.31 和 r =.54。
结论
与大量单一神经认知测试的分数相比，复合神经认知评分可能更能清楚地区分 APOE 携带者和非携带者。
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