Khalid Sidra, Daw Hamed, Jacob Miriam, Nakashima Megan
Internal Medicine, Fairview Hospital, Cleveland Clinic, Cleveland, USA.
Department of Hematology and Oncology, Fairview Hospital, Cleveland Clinic, Cleveland, USA.
Gulf J Oncolog. 2018 Jan;1(26):72-74.
T cell large granular lymphocytic leukemia is a hematological disorder which is characterized by the proliferation of CD 3+ cytotoxic T cells. We present a case about a patient who was diagnosed with T cell large granular lymphocytic leukemia and then developed pulmonary hypertension. He was treated for his leukemia with methotrexate and simultaneously treated for his pulmonary hypertension with selexipag and ambrisentan. As his leukemia improved, we also noticed an improvement in his pulmonary hypertension from a NYHA class IV to class I. Hence, we believe there is an etiopathological link between the T cell large granular leukemia and associated pulmonary hypertension.
T细胞大颗粒淋巴细胞白血病是一种血液系统疾病，其特征为CD3+细胞毒性T细胞增殖。我们报告一例被诊断为T细胞大颗粒淋巴细胞白血病并随后发生肺动脉高压的患者。他接受了甲氨蝶呤治疗白血病，同时使用司来帕格和安立生坦治疗肺动脉高压。随着他的白血病病情改善，我们还注意到他的肺动脉高压从纽约心脏协会（NYHA）IV级改善到I级。因此，我们认为T细胞大颗粒白血病与相关肺动脉高压之间存在病因病理联系。
