伴有骨髓转移的恶性胸膜间皮瘤

Ihara Hiroaki, Harada Norihiro, Shimada Naoko, Kanamori Koichiro, Hayashi Takuo, Uekusa Toshimasa, Takahashi Kazuhisa

Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Japan.

Research Institute for Diseases of Old Ages, Juntendo University Faculty of Medicine and Graduate School of Medicine, Japan.

Intern Med. 2018 Sep 1;57(17):2541-2545. doi: 10.2169/internalmedicine.9246-17. Epub 2018 Mar 30.

A 64-year-old man with the bone marrow metastasis due to malignant pleural mesothelioma (MPM) was diagnosed with anemia, leukoerythroblastosis, thrombocytopenia, and lower back pain. A bone marrow biopsy demonstrated infiltrative malignant mesothelioma lesions in the bone marrow. The patient died within 15 days of the detection of the bone marrow involvement. Physicians should consider performing a bone marrow biopsy to diagnose bone marrow metastasis and treat patients with palliative chemotherapy at an earlier phase of the disease. To our knowledge, this is the first report of an MPM patient having bone marrow metastasis with anemia, leukoerythroblastosis, and thrombocytopenia.

一名64岁男性因恶性胸膜间皮瘤（MPM）发生骨髓转移，被诊断为贫血、幼稚粒-幼红细胞血象、血小板减少症和下背部疼痛。骨髓活检显示骨髓中有浸润性恶性间皮瘤病变。患者在检测到骨髓受累后的15天内死亡。医生应考虑进行骨髓活检以诊断骨髓转移，并在疾病的早期阶段对患者进行姑息化疗。据我们所知，这是首例MPM患者发生伴有贫血、幼稚粒-幼红细胞血象和血小板减少症的骨髓转移的报告。