新型无环吡啶硫代糖苷的设计、合成、分子对接及抗肝癌活性评价
Design, synthesis, molecular docking and anti-hepatocellular carcinoma evaluation of novel acyclic pyridine thioglycosides.
作者信息
Elgemeie Galal H, Fathy Nahed M, Farag Ayman B, Alkhursani Sheikha A
机构信息
a Chemistry Department, Faculty of Science , Helwan University , Helwan , Cairo , Egypt.
b Photochemistry Department , National Research Centre , Dokki , Cairo , Egypt.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2018 Mar 4;37(3):186-198. doi: 10.1080/15257770.2018.1450508. Epub 2018 Apr 2.
A novel series of acyclic pyridine thioglycosides has been synthesized. Evaluation of the anti proliferative activity of these compounds against HEPG-2 cell lines (liver carcinoma cell lines) shows that most of the compounds have high anti-tumor activities especially 6b, 6c, 7b and 7c. Furthermore, in the modeling study, these compounds showed that they have high binding affinity with thymidylate synthase dihydrofolate reductase (TS-DHFR).
已经合成了一系列新型的无环吡啶硫代糖苷。对这些化合物针对HEPG - 2细胞系（肝癌细胞系）的抗增殖活性评估表明，大多数化合物具有高抗肿瘤活性，尤其是6b、6c、7b和7c。此外，在模型研究中，这些化合物显示出它们与胸苷酸合成酶二氢叶酸还原酶（TS - DHFR）具有高结合亲和力。
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