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Nuss手术术后疼痛结局:硬膜外镇痛、局部麻醉持续输注及术前自我催眠训练的比较

Postoperative Pain Outcomes After Nuss Procedures: Comparison of Epidural Analgesia, Continuous Infusion of Local Anesthetic, and Preoperative Self-Hypnosis Training.

作者信息

Manworren Renee C B, Anderson Matthew N, Girard Eric D, Ruscher Kimberly A, Verissimo Ana Maria, Palac Hannah, Weiss Richard, Rader Christine, Hight Donald

机构信息

1 Department of Nursing, Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, Illinois.

2 Department of Pediatrics, Northwestern University Feinberg School of Medicine , Chicago, Illinois.

出版信息

J Laparoendosc Adv Surg Tech A. 2018 Oct;28(10):1234-1242. doi: 10.1089/lap.2017.0699. Epub 2018 Apr 2.

Abstract

BACKGROUND/PURPOSE: The Nuss procedure to correct pectus excavatum is associated with severe postoperative pain. The purpose of this retrospective study was to compare pain management outcomes of thoracic epidural analgesia and continuous infusion of local anesthetic (CILA) with and without preoperative self-hypnosis training (SHT) after Nuss procedure (4 treatment groups).

METHODS

Between February 2010 and December 2013, 24 of 53 adolescents who underwent Nuss procedure received SHT. Of these, 16 received thoracic epidural analgesia and 8 received CILA postoperatively. Of the 29 patients who did not receive SHT, 19 received thoracic epidural analgesia and 10 received CILA. All patients received intravenous patient-controlled opioid analgesia and intravenous nonsteroidal anti-inflammatory drugs (IVNSAIDs) and then were transitioned to oral opioids and NSAIDs. Postoperative mean and maximum pain scores, opioid (morphine equivalents) use and side effects, and hospital length of stay (LOS) were compared between groups.

RESULTS

Patients who received SHT reported lower mean (P = .0047) and maximum (P = .0028) pain scores and used less morphine equivalents/hour over time (P = .046) compared to patients who did not receive SHT. Patients who received thoracic epidural analgesia reported lower mean (P = .0092) and maximum (P = .0083) postoperative pain scores and used more morphine equivalents/hour (P = .01) compared to those who received CILA. In addition, patients who received SHT and CILA had shorter LOS (P = .0013) than patients who received thoracic epidural analgesia without SHT.

CONCLUSIONS

SHT before pectus excavatum repair by Nuss procedure results in less postoperative pain and requires less morphine equivalents over time for postoperative pain management. Opioid-sparing CILA, when paired with SHT, results in shorter LOS.

摘要

背景/目的:采用努斯手术治疗漏斗胸会导致严重的术后疼痛。这项回顾性研究的目的是比较努斯手术后胸段硬膜外镇痛和持续输注局部麻醉药(CILA)在有或无术前自我催眠训练(SHT)情况下的疼痛管理效果(4个治疗组)。

方法

在2010年2月至2013年12月期间,53例行努斯手术的青少年中有24例接受了SHT。其中,16例术后接受胸段硬膜外镇痛,8例接受CILA。在未接受SHT的29例患者中,19例接受胸段硬膜外镇痛,10例接受CILA。所有患者均接受静脉自控阿片类镇痛和静脉非甾体抗炎药(IVNSAIDs),然后过渡到口服阿片类药物和NSAIDs。比较各治疗组间术后平均和最大疼痛评分、阿片类药物(吗啡当量)使用情况及副作用,以及住院时间(LOS)。

结果

与未接受SHT的患者相比,接受SHT的患者报告的平均疼痛评分(P = 0.0047)和最大疼痛评分(P = 0.0028)更低,且随着时间推移每小时使用的吗啡当量更少(P = 0.046)。与接受CILA的患者相比,接受胸段硬膜外镇痛的患者报告的术后平均疼痛评分(P = 0.0092)和最大疼痛评分(P = 0.0083)更低,但每小时使用的吗啡当量更多(P = 0.01)。此外,接受SHT和CILA的患者的住院时间比未接受SHT的胸段硬膜外镇痛患者更短(P = 0.0013)。

结论

在采用努斯手术修复漏斗胸之前进行SHT可减轻术后疼痛,且随着时间推移术后疼痛管理所需的吗啡当量更少。与SHT联合使用时,阿片类药物节省型CILA可缩短住院时间。

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