Department of Biostatistics, Center for Occupational Biostatistics and Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA (Dr Liu and Dr Marsh); Department of Pathology, Duke University Medical Center, Durham, NC (Dr Roggli).
J Occup Environ Med. 2018 Jul;60(7):661-671. doi: 10.1097/JOM.0000000000001320.
The aim of the study was to reanalyze an updated database of lung asbestos fiber levels for 21 brake repair workers who died of mesothelioma using robust maximum likelihood-based regression methods to address nondetectable measurements.
We applied bivariate normal regression to address the doubly left-censored situation where both the lung fiber concentration of noncommercial (TAA) and commercial amphiboles (AC) were subject to detection limits. For the single left-censored situation, we applied censored normal regression to study the relationship between duration of employment (DOE) and TAA.
We found a statistically significant positive relationship between TAA and AC (β = 0.49, 95% confidence interval [CI], 0.11 to 0.86) and a not statistically significant relationship between DOE and TAA (β = 0.02, 95% CI, -0.03 to 0.06).
Our results provide additional support for the conclusion that exposure to commercial amphibole asbestos, and not chrysotile, is related to the occurrence of mesothelioma among some brake workers.
本研究旨在使用稳健的最大似然回归方法重新分析 21 名死于间皮瘤的制动维修工人的肺部石棉纤维水平的最新数据库，以解决无法检测到的测量问题。
我们应用双变量正态回归来解决双左截断情况，即非商业（TAA）和商业角闪石（AC）的肺纤维浓度都受到检测极限的限制。对于单左截断情况，我们应用截尾正态回归来研究工龄（DOE）与 TAA 之间的关系。
我们发现 TAA 与 AC 之间存在统计学上显著的正相关关系（β=0.49，95%置信区间[CI]，0.11 至 0.86），而 DOE 与 TAA 之间的关系不具有统计学意义（β=0.02，95%CI，-0.03 至 0.06）。
我们的结果为这样的结论提供了额外的支持，即接触商业角闪石石棉，而不是温石棉，与某些制动工人间皮瘤的发生有关。
