The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; School of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China.
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; School of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China; Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:7-15. doi: 10.1016/j.pnpbp.2018.03.020. Epub 2018 Mar 30.
Dysfunctional and abnormal functional connectivity in the right anterior insula (rAI) may underlie the pathophysiology of depression episode in bipolar disorder (BD) and of major depressive disorder (MDD). In this study, we examined the dynamic functional connectivity (dFC) of the rAI of 30 patients with BD, 30 patients with MDD, and 30 healthy controls. In the functional separation of rAI, the right dorsal AI (rdAI) and ventral AI (rvAI) were defined as seed regions. Sliding-window correlation of rAI subregions was implemented to measure the variance of dFC. BD and MDD shared abnormality in dFC, such as the decreased dFC between the rvAI and right ventrolateral prefrontal cortex. Others were disorder-specific and included MDD-related increases in dFC between the rvAI and right precuneus, temporal pole, and left dorsolateral prefrontal cortex. This observation is in stark contrast to BD-related increases in the dFC between the rdAI and left inferior parietal lobule and right middle occipital gyrus. The abnormal dFC of rAI shared by BD and MDD supports the importance of rAI in the common pathophysiology of these disorders. Meanwhile, disorder-specific abnormalities that attribute to the dorsal and ventral divisions of rAI can be used as biomarkers to differentiate BD from MDD.
右侧前脑岛（rAI）功能失调和异常功能连接可能是双相障碍（BD）和重度抑郁症（MDD）发作的病理生理学基础。在这项研究中，我们检查了 30 名 BD 患者、30 名 MDD 患者和 30 名健康对照者的 rAI 的动态功能连接（dFC）。在 rAI 的功能分离中，将右背侧 AI（rdAI）和腹侧 AI（rvAI）定义为种子区域。实施 rAI 亚区的滑动窗口相关来测量 dFC 的方差。BD 和 MDD 在 dFC 方面存在共同的异常，例如 rvAI 与右侧腹外侧前额叶皮层之间的 dFC 降低。其他则是疾病特异性的，包括 MDD 相关的 rvAI 与右侧顶下小叶、颞极和左侧背外侧前额叶皮层之间的 dFC 增加。这一观察结果与 BD 相关的 rdAI 与左侧顶下小叶和右侧中枕叶回之间的 dFC 增加形成鲜明对比。BD 和 MDD 共同存在的 rAI 异常 dFC 支持 rAI 在这些疾病共同病理生理学中的重要性。同时，归因于 rAI 的背侧和腹侧分裂的疾病特异性异常可以用作区分 BD 与 MDD 的生物标志物。
