The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, China.
Hum Brain Mapp. 2020 Aug 15;41(12):3295-3304. doi: 10.1002/hbm.25017. Epub 2020 May 13.
The clinical misdiagnosis ratio of bipolar disorder (BD) patients to major depressive disorder (MDD) patients is high. Recent findings hypothesize that the ability to flexibly recruit functional neural networks is differently altered in BD and MDD patients. This study aimed to explore distinct aberrance of network flexibility during dynamic networks configuration in BD and MDD patients. Resting state functional magnetic resonance imaging of 40 BD patients, 61 MDD patients, and 61 matched healthy controls were recruited. Dynamic functional connectivity matrices for each subject were constructed with a sliding window method. Then, network switching rate of each node was calculated and compared among the three groups. BD and MDD patients shared decreased network switching rate of regions including left precuneus, bilateral parahippocampal gyrus, and bilateral dorsal medial prefrontal cortex. Apart from these regions, MDD patients presented specially decreased network switching rate in the bilateral anterior insula, left amygdala, and left striatum. Taken together, BD and MDD patients shared decreased network switching rate of key hubs in default mode network and MDD patients presented specially decreased switching rate in salience network and striatum. We found shared and distinct aberrance of network flexibility which revealed altered adaptive functions during dynamic networks configuration of BD and MDD.
双相障碍（BD）患者临床误诊为重度抑郁症（MDD）患者的比例较高。最近的研究结果假设，BD 和 MDD 患者灵活招募功能神经网络的能力存在不同程度的改变。本研究旨在探索 BD 和 MDD 患者在动态网络配置过程中网络灵活性的明显异常。招募了 40 名 BD 患者、61 名 MDD 患者和 61 名匹配的健康对照者进行静息态功能磁共振成像。采用滑动窗口方法为每个受试者构建动态功能连接矩阵。然后，计算并比较了三组中每个节点的网络切换率。BD 和 MDD 患者共享的区域包括左侧楔前叶、双侧海马旁回和双侧背内侧前额叶皮质的网络切换率降低。除了这些区域，MDD 患者的双侧前岛叶、左侧杏仁核和左侧纹状体的网络切换率也特别降低。总之，BD 和 MDD 患者共享默认模式网络中关键枢纽的网络切换率降低，而 MDD 患者在突显网络和纹状体中表现出特别降低的切换率。我们发现了网络灵活性的共享和独特异常，这揭示了 BD 和 MDD 患者在动态网络配置过程中适应性功能的改变。
