RFRP-3 对 LH 分泌的调节——从下丘脑到垂体。
Regulation of LH secretion by RFRP-3 - From the hypothalamus to the pituitary.
机构信息
Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; Department of Obstetrics and Gynaecology, University of British Columbia, British Columbia Children's Hospital Research Institute, Vancouver, British Columbia V5Z 4H4, Canada.
出版信息
Front Neuroendocrinol. 2019 Jan;52:12-21. doi: 10.1016/j.yfrne.2018.03.005. Epub 2018 Mar 30.
RFamide-related peptides (RFRPs) have long been identified as inhibitors of the hypothalamus-pituitary-gonad axis in mammals. However, less progress has been made in the detailed roles of RFRPs in the control of LH secretion. Recent studies have suggested that RFRP-3 neurons in the hypothalamus can regulate the secretion of LH at different levels, including kisspeptin neurons, GnRH neurons, and the pituitary. Additionally, conflicting results regarding the effects of RFRP-3 on these levels exist. In this review, we collect the latest evidence related to the effects of RFRP-3 neurons in regulating LH secretion by acting on kisspeptin neurons, GnRH neurons, and the pituitary and discuss the potential role of the timely reduction of RFRP-3 signaling in the modulation of the preovulatory LH surge.
RF 酰胺相关肽（RFRPs）长期以来被认为是哺乳动物下丘脑-垂体-性腺轴的抑制剂。然而，在 RFRP 对 LH 分泌的控制中的详细作用方面进展较少。最近的研究表明，下丘脑的 RFRP-3 神经元可以在不同水平上调节 LH 的分泌，包括 kisspeptin 神经元、GnRH 神经元和垂体。此外，关于 RFRP-3 对这些水平的影响存在相互矛盾的结果。在这篇综述中，我们收集了最新的证据，证明 RFRP-3 神经元通过作用于 kisspeptin 神经元、GnRH 神经元和垂体来调节 LH 分泌，并讨论了 RFRP-3 信号的及时减少在调节促排卵 LH 峰中的潜在作用。
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