Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Sección de Hemodinámica y Cardiología Intervencionista, Servicio de Cardiología, Hospital Universitario Central de Asturias, Oviedo, Spain.
Clin Immunol. 2018 Jul;192:20-29. doi: 10.1016/j.clim.2018.03.015. Epub 2018 Mar 30.
Immunosenescence in chronic heart failure (CHF) is characterized by a high frequency of differentiated T-lymphocytes, contributing to an inflammatory status and a deficient ability to generate immunocompetent responses. CMV is the best known inducer of T-lymphocyte differentiation, and is associated with the phenomenon of immunosenescence. In this study, we included 58 elderly chronic heart failure patients (ECHF), 60 healthy elderly controls (HEC), 40 young chronic heart failure patients (YCHF) and 40 healthy young controls (HYC). High differentiation of CD8+ T-lymphocytes was found in CMV-seropositive patients; however, the differentiation of CD4+ T-lymphocytes was increased in CMV-seropositive but also in CHF patients. Anti-CMV antibody titers showed positive correlation with more differentiated CD4+ and CD8+ subsets and inverse correlation with CD4/CD8 ratio. Immunosenescence found in CHF patients is mainly due to the dynamics of CMV-infection, since the differentiation of T-lymphocyte subsets is related not only to CMV-infection, but also to anti-CMV antibody titers.
免疫衰老在慢性心力衰竭（CHF）中的特征是分化的 T 淋巴细胞频率较高，导致炎症状态和产生免疫应答的能力不足。CMV 是最著名的 T 淋巴细胞分化诱导物，与免疫衰老现象相关。在这项研究中，我们纳入了 58 名老年慢性心力衰竭患者（ECHF）、60 名健康老年对照者（HEC）、40 名年轻慢性心力衰竭患者（YCHF）和 40 名健康年轻对照者（HYC）。CMV 血清阳性患者中发现 CD8+ T 淋巴细胞高度分化；然而，CMV 血清阳性和心力衰竭患者的 CD4+ T 淋巴细胞分化增加。抗 CMV 抗体滴度与分化程度更高的 CD4+和 CD8+亚群呈正相关，与 CD4/CD8 比值呈负相关。在 CHF 患者中发现的免疫衰老主要归因于 CMV 感染的动态变化，因为 T 淋巴细胞亚群的分化不仅与 CMV 感染有关，还与抗 CMV 抗体滴度有关。
