Shao D T, Wei W W
Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Mar 10;39(3):382-386. doi: 10.3760/cma.j.issn.0254-6450.2018.03.025.
With the widely application of the metagenomics, the relationship between microbiota and disease has become a hot research topic. Understanding the potential association between upper gastrointestinal cancer or precancerous lesions and microbiota may play an important role in the early detection, clinical diagnosis and treatment, and prognostic evaluation of upper gastrointestinal cancer. Therefore, a literature retrieval was conducted by using PubMed, Embase and wanfang databases to summarize the latest research progress in the microbiota of upper gastrointestinal cancer, including oral, esophageal, gastric cancer and precancerous lesions. Lower microbial diversity or richness in esophageal cancer and precancerous lesions and specific prognostic biomarkers for esophageal cancer were found. Lactobacillus richness showed an increase trend during the process from gastritis to gastric cancer. This paper summarizes the progress in the research of potential biological etiology of upper gastrointestinal cancer from the perspective of metagenomics in order to provide evidence on the, prevention and control of upper gastrointestinal cancer.
随着宏基因组学的广泛应用，微生物群与疾病之间的关系已成为热门研究课题。了解上消化道癌或癌前病变与微生物群之间的潜在关联，可能在上消化道癌的早期检测、临床诊断与治疗以及预后评估中发挥重要作用。因此，通过使用PubMed、Embase和万方数据库进行文献检索，以总结上消化道癌微生物群的最新研究进展，包括口腔、食管癌、胃癌及癌前病变。研究发现食管癌及癌前病变中微生物多样性或丰富度较低，以及食管癌的特定预后生物标志物。从胃炎到胃癌的过程中，乳酸杆菌丰富度呈上升趋势。本文从宏基因组学角度总结上消化道癌潜在生物学病因的研究进展，以便为上消化道癌的防控提供依据。
