Wang Y P, Yao S H, Liu D, Shen T, Zhao W, Gao W, Xu S L
Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHFPC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Beijing 100191, China.
Zhonghua Yi Xue Za Zhi. 2018 Mar 20;98(11):831-836. doi: 10.3760/cma.j.issn.0376-2491.2018.11.008.
To determine the relative percentage of skeletal muscle mass (SMM) in elderly patients with coronary heart disease, analyse the relationship between percentage of SMM and cardiorespiratory fitness (CRF), predict exercise capacity and cardiac reserve. Patients aged 65 years and over after PCI, receiving cardiopulmonary exercise testing (CPET) during February 2014 to December 2016 in Department of Cardiology at Peking University Third Hospital were enrolled.All patients' basic data, percentage of SMM and CPET related parameters, including peak oxygen uptake (VO(2)peak), oxygen pulse (VO(2)/HR), oxygen uptake efficiency slope (OUES) and other cardiorespiratory endurance indicators were collected, to do correlation analysis. There were 402 patients enrolled, with average age (71±5) years, including 283 cases of male (70.40%) and 119 cases of female patients (29.60%). There were 62 patients with acute myocardial infarction (15.42%), 113 patients with old myocardial infarction (28.11%), and 227 patients diagnosed with angina pectoris (56.47%). The percentage of SMM was correlated to CRF.The percentage of SMM[97.00 (92.05, 102.10)%] and VO(2)/HR (=0.231, <0.001) and OUES (=0.264, <0.001) were positively correlated.Body mass index was negatively correlated with VO(2)peak(=-0.162, =0.001). Visceral fat area (VFA) was also negatively correlated with VO(2)peak(=-0.126, =0.016). Multiple linear regression analysis showed that Body mass index and VFA were negatively correlated with VO(2)peak (=-0.204, =0.014; =-0.031, =0.013). The percentage of SMM was positively independently correlated with OUES(=11.020, <0.001). Muscle content is positively correlated with exercise capacity of patients.The percentage of skeletal muscle mass determines the core index of cardiorespiratory fitness, such as the slope of oxygen pulse and oxygen uptake efficiency.These indexes can be used as an important criterion for predicting and guiding rehabilitation exercise in patients with coronary heart disease.
为确定老年冠心病患者骨骼肌质量（SMM）的相对百分比，分析SMM百分比与心肺适能（CRF）之间的关系，预测运动能力和心脏储备。纳入2014年2月至2016年12月在北京大学第三医院心内科接受经皮冠状动脉介入治疗（PCI）后年龄在65岁及以上且接受心肺运动试验（CPET）的患者。收集所有患者的基本资料、SMM百分比及CPET相关参数，包括峰值摄氧量（VO₂peak）、氧脉搏（VO₂/HR）、摄氧效率斜率（OUES）等心肺耐力指标，进行相关性分析。共纳入402例患者，平均年龄（71±5）岁，其中男性283例（70.40%），女性119例（29.60%）。急性心肌梗死患者62例（15.42%），陈旧性心肌梗死患者113例（28.11%），诊断为心绞痛患者227例（56.47%）。SMM百分比与CRF相关。SMM百分比[97.00（92.05，102.10）%]与VO₂/HR（=0.231，<0.001）和OUES（=0.264，<0.001）呈正相关。体重指数与VO₂peak呈负相关（=-0.162，=0.001）。内脏脂肪面积（VFA）也与VO₂peak呈负相关（=-0.126，=0.016）。多元线性回归分析显示，体重指数和VFA与VO₂peak呈负相关（=-0.204，=0.014；=-0.031，=0.013）。SMM百分比与OUES呈正独立相关（=11.020，<0.001）。肌肉含量与患者运动能力呈正相关。骨骼肌质量百分比决定了心肺适能的核心指标，如氧脉搏斜率和摄氧效率。这些指标可作为预测和指导冠心病患者康复运动的重要标准。
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