Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Iksan, Republic of Korea.
Department of Preventive Medicine, Wonkwang University School of Medicine, Iksan, Republic of Korea.
Aging Clin Exp Res. 2019 Jan;31(1):49-57. doi: 10.1007/s40520-018-0987-9. Epub 2018 Jun 18.
Sarcopenia reduces physical ability and cardiorespiratory fitness (CRF), leading to poor quality of life.
The aim of this study was to investigate the relationship between skeletal muscle mass and CRF in elderly men.
We assessed 102 community-dwelling men over 60 years old. Appendicular skeletal muscle mass (ASM) was determined using bioelectrical impedance analysis, and the skeletal muscle mass index (SMI) was calculated as ASM divided by the square of height. Subjects with an SMI less than 7.0 kg/m were included in the sarcopenic group, as recommended by the Asian Working Group for Sarcopenia. To investigate CRF parameters, a cardiopulmonary exercise test was performed using the Bruce protocol. CRF parameters were subdivided into aerobic capacity, cardiovascular response, and ventilatory response.
Of the 102 subjects, 15 (14.7%) were included in the sarcopenic group. There were significant correlations between SMI and peak oxygen consumption (VO) (r = 0.597, p < 0.001), and between SMI and VO/weight (r = 0.268, p = 0.024). Moreover, there were positive correlations between SMI and first ventilatory threshold (VT1) (r = 0.352, p = 0.008) and between SMI and VT1/weight (r = 0.189, p = 0.039). Additionally, peak oxygen pulse (Opulse) was significantly correlated with SMI (r = 0.558, p < 0.001). VO, VO/weight and Opulse showed significant differences between the sarcopenic and non-sarcopenic groups (p < 0.05, all). In multiple linear regression analyses, the factor related to VO was SMI (β = 0.473, p < 0.001) and that related to Opulse was also SMI (β = 0.442, p < 0.001).
This study demonstrated that skeletal muscle mass might be closely associated with CRF. Therefore, sarcopenia should be appropriately managed to improve an individual's CRF.
肌少症降低了身体能力和心肺功能（CRF），导致生活质量下降。
本研究旨在探讨老年男性骨骼肌质量与 CRF 的关系。
我们评估了 102 名 60 岁以上的社区居住男性。使用生物电阻抗分析测定四肢骨骼肌质量（ASM），并计算骨骼肌质量指数（SMI），即 ASM 除以身高的平方。根据亚洲肌少症工作组的建议，将 SMI 小于 7.0 kg/m2 的患者纳入肌少症组。为了研究 CRF 参数，使用 Bruce 方案进行心肺运动试验。将 CRF 参数细分为有氧能力、心血管反应和通气反应。
在 102 名受试者中，有 15 名（14.7%）被纳入肌少症组。SMI 与峰值摄氧量（VO）呈显著正相关（r=0.597，p<0.001），与 VO/体重呈显著正相关（r=0.268，p=0.024）。此外，SMI 与第一通气阈值（VT1）呈正相关（r=0.352，p=0.008），与 VT1/体重呈正相关（r=0.189，p=0.039）。此外，峰值氧脉搏（Opulse）与 SMI 显著相关（r=0.558，p<0.001）。VO、VO/体重和 Opulse 在肌少症组和非肌少症组之间差异显著（p<0.05，均）。在多元线性回归分析中，与 VO 相关的因素是 SMI（β=0.473，p<0.001），与 Opulse 相关的因素也是 SMI（β=0.442，p<0.001）。
本研究表明，骨骼肌质量可能与 CRF 密切相关。因此，应适当管理肌少症以改善个体的 CRF。
