Willis G L
Monash University, Department of Psychological Medicine Prince Henry's Hospital, Melbourne, Victoria, Australia.
Pharmacol Biochem Behav. 1987 Oct;28(2):197-202. doi: 10.1016/0091-3057(87)90214-0.
Morphine (1 or 10 micrograms in 1 microliter) or beta-endorphin (1 microgram in 1 microliter) were injected bilaterally into the posterior lateral hypothalamus of Sprague-Dawley rats to determine what effect they may have on motor performance. Severe reductions in open field performance and motor reflex control were observed after the injection of 1 microgram of beta-endorphin or morphine into this area. The injection of 10 micrograms of morphine into the same area was less effective in causing motor impairment. The central (32.7 micrograms in 1 microliter) and peripheral (2 mg/kg) injection of naloxone did not prevent the motor impairment observed after the injection of beta-endorphin or morphine. Pretreatment with 6-hydroxydopamine into the lateral hypothalamus in a multistage regime did not prevent the motor impairment observed after beta-endorphin or morphine injection. These results indicate that lateral hypothalamic participation in the control of motor function may not involve the ascending nigrostriatal and mesocortical dopamine systems and that endogenous opiate systems may function independently to influence motor performance.
将吗啡（1微升含1或10微克）或β-内啡肽（1微升含1微克）双侧注射到Sprague-Dawley大鼠的下丘脑后外侧，以确定它们对运动表现可能产生的影响。向该区域注射1微克β-内啡肽或吗啡后，观察到旷场行为表现和运动反射控制严重下降。向同一区域注射10微克吗啡导致运动障碍的效果较差。中枢注射（1微升含32.7微克）和外周注射（2毫克/千克）纳洛酮并不能预防注射β-内啡肽或吗啡后观察到的运动障碍。采用多阶段方案向下丘脑外侧注射6-羟基多巴胺并不能预防注射β-内啡肽或吗啡后观察到的运动障碍。这些结果表明，下丘脑外侧参与运动功能控制可能不涉及黑质纹状体和中皮质多巴胺系统的上行通路，内源性阿片系统可能独立发挥作用来影响运动表现。
