Cardiovascular Clinic Bad Neustadt, Bad Neustadt, Germany.
Cardiovascular Clinic Bad Neustadt, Bad Neustadt, Germany.
J Thorac Cardiovasc Surg. 2018 Jul;156(1):89-95.e2. doi: 10.1016/j.jtcvs.2018.01.105. Epub 2018 Mar 11.
The aim of this study was to evaluate surgical results of complete aortic root replacement using self-assembled valve composite graft in the setting of destroyed aortic annulus after previous valve replacement.
Aortic root pathology being addressed by complete root replacement was combined with partial or complete absence of annular tissue in 112 consecutive patients. Eighty-eight had undergone a previous replacement of the aortic valve and 24 had undergone root replacement with a valved conduit. Altogether, 31 patients (27.7%) presented with acute endocarditis, which was the indication for surgery in 75% of patients with prior root replacement. In all patients, the root replacement or re-replacement was performed with a self-assembled valved conduit using mechanical (n = 74) or, in patients with an advanced age, biological (n = 38) valve prostheses.
In-hospital mortality was 11.6%, including a 30-day mortality of 6.3%. Resternotomy for bleeding was necessary in 5.4% of patients and about one-quarter did not need any blood transfusion. Estimated survival at 1, 5, and 10 years was 84.8% ± 3.4%, 75.7% ± 4.3%, and 57.1% ± 6.5%, respectively. Freedom from any valve-related events at 10 years was 86.2% ± 4.1%. During the follow-up time (mean, 63 ± 47 months), there was only 1 reoperation necessary 9 years after surgery (replacement of deteriorated biological valve prosthesis within the vascular tube leaving the conduit untouched).
A self-assembled composite graft allows safe proximal fixation of the conduit in patients with destroyed aortic annulus, resulting in sufficient proximal anastomosis and a very low incidence of aorta-related reoperations.
本研究旨在评估在先前瓣膜置换术后破坏的主动脉瓣环的情况下,使用自组装瓣膜复合移植物进行全主动脉根部置换的手术结果。
112 例连续患者的主动脉根部病变采用全根部置换,其中部分或完全缺乏瓣环组织。88 例患者曾行主动脉瓣置换,24 例患者曾行带瓣管道根部置换。共有 31 例(27.7%)患者患有急性心内膜炎,其中 75%的患者因心内膜炎而行手术。所有患者均采用自组装带瓣管道行根部置换或再次置换,其中 74 例患者采用机械瓣膜(n=74),38 例患者因高龄而采用生物瓣膜(n=38)。
院内死亡率为 11.6%,其中 30 天死亡率为 6.3%。5.4%的患者需要再次开胸止血,约四分之一的患者不需要输血。1、5 和 10 年的估计生存率分别为 84.8%±3.4%、75.7%±4.3%和 57.1%±6.5%。10 年时无任何瓣膜相关事件的生存率为 86.2%±4.1%。在随访期间(平均 63±47 个月),仅在术后 9 年需要再次手术 1 例(更换血管内血管内恶化的生物瓣膜假体,而不触及移植物)。
自组装复合移植物可安全地固定在破坏的主动脉瓣环患者的管道近端,从而实现足够的近端吻合,且主动脉相关再次手术的发生率非常低。