Department of Biology, University of Rome TorVergata, 00133 Rome, Italy; Regina Elena National Cancer Institute, 00144 Rome, Italy.
Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, United Kingdom; University College London Consortium for Mitochondrial Research, University College London, London WC1 6BT, United Kingdom.
Trends Pharmacol Sci. 2018 May;39(5):437-439. doi: 10.1016/j.tips.2018.02.008. Epub 2018 Mar 30.
The complex biochemistry and dynamic structure of mitochondria have prevented them from being prominent pharmacological targets. New mechanistic understanding of cholesterol transport and associated neurosteroidogenesis is providing evidence on therapeutic outcomes in mental disorders that is achievable via mitochondrial pharmacology. This warrants general attention on mitochondrial pharmacology to inform therapies.
线粒体复杂的生物化学和动态结构使其难以成为突出的药理学靶点。胆固醇转运和相关神经甾体生成的新机制理解为通过线粒体药理学实现精神障碍治疗结果提供了证据。这就需要对线粒体药理学给予普遍关注，以为治疗提供信息。
