Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Department of Neurology, Johns Hopkins University, Baltimore, MD, United States.
Brain Lang. 2019 Jun;193:4-9. doi: 10.1016/j.bandl.2017.12.005. Epub 2018 Mar 31.
To examine the impact of diverse syndromes of focal and generalized epilepsy on language function in children with new and recent onset epilepsy. Of special interest was the degree of shared language abnormality across epilepsy syndromes and the unique effects associated with specific epilepsy syndromes.
Participants were 136 youth with new or recent-onset (diagnosis within past 12 months) epilepsy and 107 healthy first-degree cousin controls. The participants with epilepsy included 20 with Temporal Lobe Epilepsy (TLE; M age = 12.99 years, SD = 3.11), 41 with Benign Epilepsy with Centrotemporal Spikes (BECTS; M age = 10.32, SD = 1.67), 42 with Juvenile Myoclonic Epilepsy (JME; M age = 14.85, SD = 2.75) and 33 with absence epilepsy (M age = 10.55, SD = 2.76). All children were administered a comprehensive test battery which included multiple measures of language and language-dependent abilities (i.e., verbal intelligence, vocabulary, verbal reasoning, object naming, reception word recognition, word reading, spelling, lexical and semantic fluency, verbal list learning and delayed verbal memory). Test scores were adjusted for age and gender and analyzed via MANCOVA.
Language abnormalities were found in all epilepsy patient groups. The most broadly affected children were those with TLE and absence epilepsy, whose performance differed significantly from controls on 8 of 11 and 9 of 11 tests respectively. Although children with JME and BECTS were less affected, significant differences from controls were found on 4 of 11 tests each. While each group had a unique profile of language deficits, commonalities were apparent across both idiopathic generalized and localization-related diagnostic categories.
The localization related and generalized idiopathic childhood epilepsies examined here were associated with impact on diverse language abilities early in the course of the disorder.
研究局灶性和全面性癫痫综合征对新发和近期发作癫痫儿童语言功能的影响。特别关注的是各种癫痫综合征之间语言异常的程度，以及与特定癫痫综合征相关的独特影响。
参与者为 136 名新发病或近期发病（发病时间在过去 12 个月内）的癫痫儿童和 107 名健康的一级表亲对照。癫痫患儿包括 20 名颞叶癫痫（TLE；M 年龄=12.99 岁，SD=3.11），41 名良性癫痫伴中央颞区棘波（BECTS；M 年龄=10.32 岁，SD=1.67），42 名青少年肌阵挛性癫痫（JME；M 年龄=14.85 岁，SD=2.75）和 33 名失神癫痫（M 年龄=10.55 岁，SD=2.76）。所有儿童均接受了综合测试，包括多种语言和语言相关能力的测试（即言语智力、词汇、言语推理、物体命名、接受性词语识别、单词阅读、拼写、词汇和语义流畅性、词语列表学习和延迟言语记忆）。测试成绩根据年龄和性别进行调整，并通过 MANCOVA 进行分析。
所有癫痫患者组均存在语言异常。受影响最广泛的儿童是 TLE 和失神性癫痫患儿，他们在 11 项测试中的 8 项和 9 项测试中表现明显不同于对照组。尽管 JME 和 BECTS 患儿受影响较小，但在 11 项测试中的每一项上与对照组均有显著差异。虽然每个组都有独特的语言缺陷特征，但在特发性全身性和定位相关的诊断类别中都有共同点。
这里检查的局灶性和特发性儿童癫痫与疾病早期对多种语言能力的影响有关。
