Guarnizo-Poma Mirella, Paico-Palacios Socorro, Pantoja-Torres Betzi, Lazaro-Alcantara Herbert, Urrunaga-Pastor Diego, Benites-Zapata Vicente A
Instituto Médico de la Mujer/Instituto Médico Metabólico, Lima, Peru.
Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
Diabetes Metab Syndr. 2018 Jul;12(4):531-535. doi: 10.1016/j.dsx.2018.03.023. Epub 2018 Mar 27.
To determine the association between the thyroid hormones(FT3, FT4 and TSH) and the lipid profile markers(HDL-c, LDL-c and triglycerides) values in middle-aged women with no metabolic disorders and recurrent chronic symptomatology.
We carried out an analytical cross-sectional study in euthyroid women with recurrent chronic symptoms of at least six months with no apparent diagnosis who attended the endocrinological gynaecology outpatient service of a private clinic in Lima-Peru during 2012-2014. Participants who met the eligibility criteria were evaluated according to their thyroid hormones(FT3, FT4 and TSH) and lipid profile markers(HDL-c, LDL-c and triglycerides) values. We elaborated univariate/multivariate linear regression models to evaluate the association between the thyroid markers and the lipid profile levels. The reported association measure was the beta coefficient(β) with its respective p-value.
We analyzed 211 participants, the average age was 44.9 ± 14.0(SD) years, the FT3 and FT4 mean levels were 3.2 ± 0.4 pg/mL and 1.2 ± 0.2 ng/dL respectively, while the TSH median was 2.8(IQR:1.9-4.0) μU/mL. The mean or median levels of LDL-c, HDL-c and triglycerides were of 137.5 ± 37.9 mg/dL, 54.0 ± 15.0 mg/dL and 118.5(IQR:79.5-169.5) mg/dL respectively. In the multivariate linear regression model between the FT3 and LDL-c levels, we found that for each increase in a FT3 unit, the LDL-c values decreased on average 30.85 mg/dL(p < 0.01). We found no statistically significant associations in the other multivariate models of linear regression, among the other thyroid hormones and lipid markers.
We found an inverse association between the FT3 and LDL-c values in women with chronic gynaecological symptoms.
确定无代谢紊乱及复发性慢性症状的中年女性甲状腺激素（游离三碘甲状腺原氨酸、游离甲状腺素和促甲状腺激素）与血脂谱标志物（高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯）值之间的关联。
我们对2012年至2014年期间在秘鲁利马一家私人诊所的内分泌妇科门诊就诊的甲状腺功能正常、有至少六个月复发性慢性症状且无明显诊断的女性进行了一项分析性横断面研究。符合纳入标准的参与者根据其甲状腺激素（游离三碘甲状腺原氨酸、游离甲状腺素和促甲状腺激素）及血脂谱标志物（高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯）值进行评估。我们构建了单变量/多变量线性回归模型来评估甲状腺标志物与血脂谱水平之间的关联。报告的关联度量指标为β系数及其相应的p值。
我们分析了211名参与者，平均年龄为44.9±14.0（标准差）岁，游离三碘甲状腺原氨酸和游离甲状腺素的平均水平分别为3.2±0.4 pg/mL和1.2±0.2 ng/dL，而促甲状腺激素中位数为2.8（四分位间距：1.9 - 4.0）μU/mL。低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的平均或中位数水平分别为137.5±37.9 mg/dL、54.0±15.0 mg/dL和118.5（四分位间距：79.5 - 169.5）mg/dL。在游离三碘甲状腺原氨酸与低密度脂蛋白胆固醇水平的多变量线性回归模型中，我们发现游离三碘甲状腺原氨酸每增加一个单位，低密度脂蛋白胆固醇值平均降低30.85 mg/dL（p < 0.01）。在其他甲状腺激素与血脂标志物的多变量线性回归模型中，我们未发现具有统计学意义的关联。
我们发现患有慢性妇科症状的女性中游离三碘甲状腺原氨酸与低密度脂蛋白胆固醇值之间存在负相关。
