从定植到发病：剖析肺炎链球菌的进展过程。
Deconstructing Pneumococcal Progression from Colonization to Disease.
机构信息
Boston University Schools of Medicine and Public Health and Division of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts, USA
出版信息
Infect Immun. 2018 May 22;86(6). doi: 10.1128/IAI.00225-18. Print 2018 Jun.
Abstract
Despite advances in treatment and prevention, the pneumococcus continues to be a dominant cause of severe pneumonia and sepsis and of otitis media, sinusitis, and nonbacteremic pneumonia. Lewnard and colleagues (Infect Immun 86:e00727-17, 2018, https://doi.org/10.1128/IAI.00727-17) used a unique data set of nasopharyngeal and middle ear fluid samples to provide further insight into the progression of nasopharyngeal pneumococcal colonization to disease. They report the comparative rate of progression from colonization to otitis media by serotype, providing insight into how conjugate vaccines that do not reduce the overall prevalence of pneumococci in the nasopharynx dramatically impact the incidence of acute and complex otitis media.
摘要
尽管在治疗和预防方面取得了进展，但肺炎球菌仍然是严重肺炎和败血症以及中耳炎、鼻窦炎和非菌血症性肺炎的主要病因。Lewnard 及其同事（Infect Immun 86:e00727-17, 2018, https://doi.org/10.1128/IAI.00727-17）使用鼻咽和中耳液样本的独特数据集，进一步深入了解鼻咽肺炎球菌定植向疾病的进展。他们报告了不同血清型从定植到中耳炎进展的比较速率，深入了解了不降低鼻咽肺炎球菌总体流行率的结合疫苗如何显著影响急性和复杂性中耳炎的发病率。
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