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从定植到发病：剖析肺炎链球菌的进展过程。

Deconstructing Pneumococcal Progression from Colonization to Disease.

机构信息

Boston University Schools of Medicine and Public Health and Division of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts, USA

出版信息

Infect Immun. 2018 May 22;86(6). doi: 10.1128/IAI.00225-18. Print 2018 Jun.

DOI:10.1128/IAI.00225-18
PMID:29610253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5964524/
Abstract

Despite advances in treatment and prevention, the pneumococcus continues to be a dominant cause of severe pneumonia and sepsis and of otitis media, sinusitis, and nonbacteremic pneumonia. Lewnard and colleagues (Infect Immun 86:e00727-17, 2018, https://doi.org/10.1128/IAI.00727-17) used a unique data set of nasopharyngeal and middle ear fluid samples to provide further insight into the progression of nasopharyngeal pneumococcal colonization to disease. They report the comparative rate of progression from colonization to otitis media by serotype, providing insight into how conjugate vaccines that do not reduce the overall prevalence of pneumococci in the nasopharynx dramatically impact the incidence of acute and complex otitis media.

摘要

尽管在治疗和预防方面取得了进展，但肺炎球菌仍然是严重肺炎和败血症以及中耳炎、鼻窦炎和非菌血症性肺炎的主要病因。Lewnard 及其同事（Infect Immun 86:e00727-17, 2018, https://doi.org/10.1128/IAI.00727-17）使用鼻咽和中耳液样本的独特数据集，进一步深入了解鼻咽肺炎球菌定植向疾病的进展。他们报告了不同血清型从定植到中耳炎进展的比较速率，深入了解了不降低鼻咽肺炎球菌总体流行率的结合疫苗如何显著影响急性和复杂性中耳炎的发病率。

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引用本文的文献

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Clin Exp Pediatr. 2021 Nov;64(11):543-551. doi: 10.3345/cep.2020.01452. Epub 2021 Apr 15.

本文引用的文献

1
Pneumococcal Phenotype and Interaction with Nontypeable Haemophilus influenzae as Determinants of Otitis Media Progression.肺炎球菌表型与不典型流感嗜血杆菌相互作用作为中耳炎进展的决定因素。
Infect Immun. 2018 May 22;86(6). doi: 10.1128/IAI.00727-17. Print 2018 Jun.
2
Relating Pneumococcal Carriage Among Children to Disease Rates Among Adults Before and After the Introduction of Conjugate Vaccines.在引入结合疫苗前后，将儿童肺炎球菌携带情况与成人疾病发病率相关联。
Am J Epidemiol. 2016 Jun 1;183(11):1055-62. doi: 10.1093/aje/kwv283. Epub 2016 May 2.
3
Mechanisms of Bacterial Colonization of the Respiratory Tract.呼吸道细菌定植的机制
Annu Rev Microbiol. 2015;69:425-44. doi: 10.1146/annurev-micro-091014-104209.
4
Rethinking risk for pneumococcal disease in adults: the role of risk stacking.重新思考成人肺炎球菌病的风险：风险叠加的作用。
Open Forum Infect Dis. 2015 Mar 20;2(1):ofv020. doi: 10.1093/ofid/ofv020. eCollection 2015 Jan.
5
Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance.13 价肺炎球菌结合疫苗在儿童中的使用对美国儿童和成人侵袭性肺炎球菌病的影响：基于多地点、人群的监测分析。
Lancet Infect Dis. 2015 Mar;15(3):301-9. doi: 10.1016/S1473-3099(14)71081-3. Epub 2015 Feb 3.
6
The fundamental link between pneumococcal carriage and disease.肺炎球菌带菌与疾病之间的根本联系。
Expert Rev Vaccines. 2012 Jul;11(7):841-55. doi: 10.1586/erv.12.53.
7
When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media.当流感嗜血杆菌与肺炎链球菌共同定植于鼻咽部时，除 19A 血清型菌株外，流感嗜血杆菌会占优势引起急性中耳炎。
Pediatr Infect Dis J. 2012 Jun;31(6):638-40. doi: 10.1097/INF.0b013e31824ba6f7.
8
Viral upper respiratory tract infection and otitis media complication in young children.幼儿的病毒性上呼吸道感染及中耳炎并发症
Clin Infect Dis. 2008 Mar 15;46(6):815-23. doi: 10.1086/528685.
9
Association of nasopharyngeal bacterial colonization during upper respiratory tract infection and the development of acute otitis media.上呼吸道感染期间鼻咽部细菌定植与急性中耳炎发生的关联。
Clin Infect Dis. 2008 Feb 15;46(4):e34-7. doi: 10.1086/525856.
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The value of nasopharyngeal culture in predicting the etiology of acute otitis media in children less than two years of age.鼻咽部培养在预测两岁以下儿童急性中耳炎病因方面的价值。
Pediatr Infect Dis J. 2006 Nov;25(11):1032-6. doi: 10.1097/01.inf.0000241097.37428.1d.