• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

当流感嗜血杆菌与肺炎链球菌共同定植于鼻咽部时，除 19A 血清型菌株外，流感嗜血杆菌会占优势引起急性中耳炎。

When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media.

机构信息

Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA.

出版信息

Pediatr Infect Dis J. 2012 Jun;31(6):638-40. doi: 10.1097/INF.0b013e31824ba6f7.

DOI:10.1097/INF.0b013e31824ba6f7
PMID:22301480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3356506/
Abstract

Of 368 acute otitis media (AOM) cases among 7-valent pneumococcal conjugate-vaccinated children, 43.5% were colonized by multiple otopathogens in the nasopharynx but only 7.1% experienced polymicrobial AOM. When co-colonization occurred, Haemophilus influenzae predominated over all Streptococcus pneumoniae strains except 19A strains to cause AOM. Haemophilus influenzae and Streptococcus pneumoniae both predominated over Moraxella catarrhalis to cause AOM.

摘要

在 7 价肺炎球菌结合疫苗接种儿童的 368 例急性中耳炎 (AOM) 病例中，43.5% 的鼻咽部存在多种鼻咽病原体定植，但只有 7.1% 的儿童发生了多种微生物 AOM。当共同定植发生时，除 19A 菌株外，流感嗜血杆菌比所有肺炎链球菌菌株更易引起 AOM。流感嗜血杆菌和肺炎链球菌均比卡他莫拉菌更易引起 AOM。

相似文献

1
When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media.当流感嗜血杆菌与肺炎链球菌共同定植于鼻咽部时，除 19A 血清型菌株外，流感嗜血杆菌会占优势引起急性中耳炎。
Pediatr Infect Dis J. 2012 Jun;31(6):638-40. doi: 10.1097/INF.0b013e31824ba6f7.
2
Density, Serotype Diversity, and Fitness of Streptococcus pneumoniae in Upper Respiratory Tract Cocolonization With Nontypeable Haemophilus influenzae.肺炎链球菌与不可分型流感嗜血杆菌在上呼吸道共同定植时的密度、血清型多样性及适应性
J Infect Dis. 2016 Nov 1;214(9):1411-1420. doi: 10.1093/infdis/jiw381. Epub 2016 Aug 17.
3
New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine.接种肺炎球菌结合疫苗 6-8 年后引起急性中耳炎的耳病原体的新发病模式。
Pediatr Infect Dis J. 2010 Apr;29(4):304-9. doi: 10.1097/INF.0b013e3181c1bc48.
4
Biofilm production by Haemophilus influenzae and Streptococcus pneumoniae isolated from the nasopharynx of children with acute otitis media.从急性中耳炎患儿鼻咽部分离的流感嗜血杆菌和肺炎链球菌的生物膜生成。
BMC Infect Dis. 2019 Jan 11;19(1):44. doi: 10.1186/s12879-018-3657-9.
5
Otopathogens in the middle ear and nasopharynx of children with recurrent acute otitis media.儿童复发性急性中耳炎中耳和鼻咽部的耳病原体。
Int J Pediatr Otorhinolaryngol. 2023 Jun;169:111552. doi: 10.1016/j.ijporl.2023.111552. Epub 2023 Apr 10.
6
Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection.纽约罗切斯特市小儿急性中耳炎的五年前瞻性研究：鼻咽部肺炎球菌定植及感染风险的模型分析
Epidemiol Infect. 2014 Oct;142(10):2186-94. doi: 10.1017/S0950268813003178. Epub 2013 Dec 17.
7
Dynamic changes in otopathogens colonizing the nasopharynx and causing acute otitis media in children after 13-valent (PCV13) pneumococcal conjugate vaccination during 2015-2019.2015-2019 年 13 价（PCV13）肺炎球菌结合疫苗接种后鼻咽部定植和引起儿童急性中耳炎的耳病原体动态变化。
Eur J Clin Microbiol Infect Dis. 2022 Jan;41(1):37-44. doi: 10.1007/s10096-021-04324-0. Epub 2021 Aug 25.
8
Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule.3+0 型肺炎球菌结合疫苗接种方案实施后儿童中耳炎中不典型流感嗜血杆菌占优势。
Vaccine. 2011 Jul 18;29(32):5163-70. doi: 10.1016/j.vaccine.2011.05.035. Epub 2011 May 27.
9
Characteristics and outcomes of acute otitis media in children carrying streptococcus pneumoniae or haemophilus influenzae in their nasopharynx as a single otopathogen after introduction of the heptavalent pneumococcal conjugate vaccine.在引入七价肺炎球菌结合疫苗后，鼻咽部携带肺炎链球菌或流感嗜血杆菌作为单一耳病原体的儿童急性中耳炎的特征及转归
Pediatr Infect Dis J. 2014 May;33(5):533-6. doi: 10.1097/INF.0000000000000213.
10
Nasopharyngeal flora in children with acute otitis media before and after implementation of 7 valent pneumococcal conjugate vaccine in France.法国实施 7 价肺炎球菌结合疫苗前后儿童急性中耳炎鼻咽部菌群的变化。
BMC Infect Dis. 2012 Mar 7;12:52. doi: 10.1186/1471-2334-12-52.

引用本文的文献

1
Moraxella Catarrhalis Infrequently Cultured from Middle Ear Fluid of Children with Acute Otitis Media.卡他莫拉菌从儿童急性中耳炎中耳液中培养频率较低。
Pediatr Infect Dis J. 2023 Nov 1;42(11):e416-e417. doi: 10.1097/INF.0000000000004028. Epub 2023 Jun 30.
2
Nasopharyngeal microbiome composition associated with Streptococcus pneumoniae colonization suggests a protective role of Corynebacterium in young children.鼻咽微生物组组成与肺炎链球菌定植相关，提示棒状杆菌在幼儿中具有保护作用。
PLoS One. 2021 Sep 16;16(9):e0257207. doi: 10.1371/journal.pone.0257207. eCollection 2021.
3
Effects of nasopharyngeal microbiota in respiratory infections and allergies.鼻咽微生物群在呼吸道感染和过敏中的作用。
Clin Exp Pediatr. 2021 Nov;64(11):543-551. doi: 10.3345/cep.2020.01452. Epub 2021 Apr 15.
4
Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children.鼻咽部定植病原体与婴幼儿呼吸道疾病易感性有关。
PLoS One. 2020 Dec 11;15(12):e0243942. doi: 10.1371/journal.pone.0243942. eCollection 2020.
5
Deconstructing Pneumococcal Progression from Colonization to Disease.从定植到发病：剖析肺炎链球菌的进展过程。
Infect Immun. 2018 May 22;86(6). doi: 10.1128/IAI.00225-18. Print 2018 Jun.
6
Modeling specific antibody responses to natural immunization to predict a correlate of protection against infection before commencing a clinical vaccine trial.建立针对自然免疫的特定抗体反应模型，以在开展临床疫苗试验之前预测针对感染的保护相关因素。
Hum Vaccin Immunother. 2017 Oct 3;13(10):2316-2321. doi: 10.1080/21645515.2017.1329064.
7
Serum antibody response to Moraxella catarrhalis proteins in stringently defined otitis prone children.严格定义的易患中耳炎儿童对卡他莫拉菌蛋白的血清抗体反应。
Vaccine. 2019 Jul 26;37(32):4637-4645. doi: 10.1016/j.vaccine.2017.07.027. Epub 2017 Jul 26.
8
Otitis Media Pathogenesis and How It Informs Our Understanding of Vaccine Strategies.中耳炎的发病机制及其对我们理解疫苗策略的启示
Curr Otorhinolaryngol Rep. 2017;5(2):115-124. doi: 10.1007/s40136-017-0152-6. Epub 2017 May 20.
9
Nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection.健康状态、病毒性上呼吸道感染及上呼吸道细菌感染期间的鼻咽部多种微生物定植
J Infect. 2017 Jul;75(1):26-34. doi: 10.1016/j.jinf.2017.04.003. Epub 2017 Apr 13.
10
Epidemiology of Otitis Media with Spontaneous Perforation of the Tympanic Membrane in Young Children and Association with Bacterial Nasopharyngeal Carriage, Recurrences and Pneumococcal Vaccination in Catalonia, Spain - The Prospective HERMES Study.西班牙加泰罗尼亚地区幼儿鼓膜自发性穿孔性中耳炎的流行病学及其与鼻咽部细菌携带、复发和肺炎球菌疫苗接种的关系——前瞻性HERMES研究
PLoS One. 2017 Feb 1;12(2):e0170316. doi: 10.1371/journal.pone.0170316. eCollection 2017.

本文引用的文献

1
Phylogenetic relatedness and diversity of non-typable Haemophilus influenzae in the nasopharynx and middle ear fluid of children with acute otitis media.儿童急性中耳炎患者鼻咽和中耳液中非典型流感嗜血杆菌的系统进化关系和多样性。
J Med Microbiol. 2011 Dec;60(Pt 12):1841-1848. doi: 10.1099/jmm.0.034041-0. Epub 2011 Jul 28.
2
New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine.接种肺炎球菌结合疫苗 6-8 年后引起急性中耳炎的耳病原体的新发病模式。
Pediatr Infect Dis J. 2010 Apr;29(4):304-9. doi: 10.1097/INF.0b013e3181c1bc48.
3
Microbial interactions during upper respiratory tract infections.上呼吸道感染期间的微生物相互作用。
Emerg Infect Dis. 2008 Oct;14(10):1584-91. doi: 10.3201/eid1410.080119.
4
Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006.2003 - 2006年导致复发性及难治性急性中耳炎的病原体
Clin Pediatr (Phila). 2008 Nov;47(9):901-6. doi: 10.1177/0009922808319966. Epub 2008 Jun 16.
5
Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children.一种7价结合疫苗未涵盖的多重耐药19A血清型肺炎球菌菌株作为儿童耳病原体出现。
JAMA. 2007 Oct 17;298(15):1772-8. doi: 10.1001/jama.298.15.1772.
6
The dynamics of bacteria in the middle ear during the course of acute otitis media with tympanostomy tube otorrhea.鼓膜置管耳漏型急性中耳炎病程中中耳细菌的动态变化
Pediatr Infect Dis J. 2007 Oct;26(10):892-6. doi: 10.1097/INF.0b013e31812e4b6c.
7
Vaccine-induced pathogen strain replacement: what are the mechanisms?疫苗诱导的病原体菌株替代：机制是什么？
J R Soc Interface. 2008 Jan 6;5(18):3-13. doi: 10.1098/rsif.2007.0236.
8
The value of nasopharyngeal culture in predicting the etiology of acute otitis media in children less than two years of age.鼻咽部培养在预测两岁以下儿童急性中耳炎病因方面的价值。
Pediatr Infect Dis J. 2006 Nov;25(11):1032-6. doi: 10.1097/01.inf.0000241097.37428.1d.
9
The role of innate immune responses in the outcome of interspecies competition for colonization of mucosal surfaces.固有免疫反应在黏膜表面定植的种间竞争结果中的作用。
PLoS Pathog. 2005 Sep;1(1):e1. doi: 10.1371/journal.ppat.0010001. Epub 2005 Jul 22.
10
Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life.对一组芬兰儿童出生后头两年进行随访，观察其急性中耳炎的细菌学情况。
Pediatr Infect Dis J. 2001 Jul;20(7):654-62. doi: 10.1097/00006454-200107000-00004.