从胎儿血红蛋白向成人血红蛋白转变。
Switching from fetal to adult hemoglobin.
机构信息
National Heart, Lung and Blood Institute/NIH, Sickle Cell Branch, Bethesda, MD, USA.
出版信息
Nat Genet. 2018 Apr;50(4):478-480. doi: 10.1038/s41588-018-0094-z.
Abstract
The switch from fetal to adult hemoglobin relies on repression or silencing of the upstream γ-globin gene, but identification of the transcriptional repressors that bind to the sites at which a cluster of naturally occurring variants associated with HPFH (hereditary persistence of fetal hemoglobin) are found has been elusive. A new study provides mechanistic evidence for the direct binding of BCL11A and ZBTB7A, two previously identified γ-globin gene repressors.
摘要
从胎儿血红蛋白向成人血红蛋白的转变依赖于对上游γ-珠蛋白基因的抑制或沉默，但与 HPFH（遗传性胎儿血红蛋白持续存在）相关的自然发生变体簇所在的位点结合的转录抑制剂的鉴定一直难以捉摸。一项新的研究为 BCL11A 和 ZBTB7A 的直接结合提供了机制证据，BCL11A 和 ZBTB7A 是之前鉴定的两种γ-珠蛋白基因抑制剂。
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