Hecker M, Richter A, Schroeter A, Wölfel L, Mach F
Sektion Biologie der Ernst-Moritz-Arndt-Universität, Greifswald, Deutsche Demokratische Republik.
Z Naturforsch C J Biosci. 1987 Jul-Aug;42(7-8):941-7.
Some of the presumable heat shock proteins will be produced in Bacillus subtilis in response to different environmental conditions, e.g. heat shock, amino acid limitation or oxygen limitation. During amino acid limitation or during oxygen limitation the relA+ strain is able of synthesizing this set of proteins but the relA strain is not. We suggest that the accelerated rate of the synthesis of some heat shock proteins depends on the induction of the stringent response because the (p)ppGpp production does not occur in the relA strain during amino acid or oxygen limitation. On the other hand the relA strain can produce heat shock proteins under heat stress. Therefore different mechanisms must be responsible for the expression of this set of genes during heat and other stress stimuli. It can be supposed that in B. subtilis the (p)ppGpp-dependent stringent control is a central defense reaction against different adverse environmental conditions and furthermore, that the synthesis of "stress" proteins as an essential component of the stringent response is part of a general adaptation mechanism under non-growing conditions.
一些推测的热休克蛋白会在枯草芽孢杆菌中响应不同的环境条件而产生，例如热休克、氨基酸限制或氧气限制。在氨基酸限制或氧气限制期间，relA⁺菌株能够合成这组蛋白质，但relA菌株则不能。我们认为，一些热休克蛋白合成速率的加快取决于严格反应的诱导，因为在氨基酸或氧气限制期间，relA菌株中不会产生（p）ppGpp。另一方面，relA菌株在热应激下可以产生热休克蛋白。因此，不同的机制必定负责这组基因在热应激和其他应激刺激下的表达。可以推测，在枯草芽孢杆菌中，（p）ppGpp依赖性严格控制是针对不同不利环境条件的核心防御反应，此外，作为严格反应重要组成部分的“应激”蛋白的合成是生长停滞条件下一般适应机制的一部分。
