β-萘酚和 4-羟基香豆素与乙烯砜盐的环化反应：二氢呋喃衍生物的合成。
Annulation of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts: synthesis of dihydrofuran derivatives.
机构信息
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
出版信息
Org Biomol Chem. 2018 Apr 18;16(15):2634-2638. doi: 10.1039/c8ob00293b.
PMID:29611601
Abstract
A new synthetic approach to dihydrofuran derivatives via the annulation reaction of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts has been developed. A variety of dihydrofuran derivatives were prepared in moderate to good yields under mild conditions. The products could be readily transformed to the corresponding furans via the dehydrogenation with DDQ.
摘要
一种通过β-萘酚和 4-羟基香豆素与乙烯砜盐的环加成反应合成二氢呋喃衍生物的新方法已经开发出来。在温和条件下，通过各种二氢呋喃衍生物以中等至良好的收率制备。通过使用 DDQ 脱氢，产物可以很容易地转化为相应的呋喃。
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