辛伐他汀对猪骨髓红细胞系的影响。
Influence of simvastatin on red blood cell line in porcine bone marrow.
作者信息
Snarska A, Gonkowski S, Rytel L, Pomianowski A, Babińska I, Otrocka-Domagała I, Żarczyńska K, Wysocka D, Sobiech P
机构信息
Department and Clinic of Internal Diseases University of Warmia and Mazury in Olsztyn, Oczapowskiego 13-14, 10-719 Olsztyn, Poland.
Department of Physiology University of Warmia and Mazury in Olsztyn, Oczapowskiego 13-14, 10-719 Olsztyn, Poland.
出版信息
Pol J Vet Sci. 2017 Dec;20(4):811-814. doi: 10.1515/pjvs-2017-0093.
Simvastatin is a drug commonly used to reduce the cholesterol level. 32 clinically healthy female pigs with a bodyweight of 35-40 kg, kept in standard laboratory conditions were chosen for the experiment and divided into 2 groups (control and experimental) consisting of 16 animals. The experimental group received simvastatin orally at a dose of 40 mg (one tablet once a day) for 56 days, and at the same time the control group received placebo (empty gelatin capsules). Bone marrow smears and peripheral blood samples were evaluated. The obtained results indicate that simvastatin may inhibit erythropoiesis even after a relatively short period of administration, and observed changes can be the cause of some symptoms (for example anemia) occurring during statin therapy.
辛伐他汀是一种常用于降低胆固醇水平的药物。选取32只体重在35 - 40千克、饲养于标准实验室条件下的临床健康雌性猪用于实验，并将其分为两组（对照组和实验组），每组16只动物。实验组口服40毫克辛伐他汀（每日一片），持续56天，同时对照组服用安慰剂（空明胶胶囊）。对骨髓涂片和外周血样本进行了评估。所得结果表明，即使在相对较短的给药期后，辛伐他汀也可能抑制红细胞生成，观察到的变化可能是他汀类药物治疗期间出现某些症状（如贫血）的原因。
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