Navon R, Baram D
Department of Human Genetics, Tel Aviv University Sackler Faculty of Medicine, Israel.
Biochem Biophys Res Commun. 1987 Nov 13;148(3):1098-103. doi: 10.1016/s0006-291x(87)80245-0.
Normal human skin fibroblasts secrete most of their hexosaminidase (Hex) into the medium upon incubation with 10(-4) imipramine, while preincubation with 2.5 X 10(-9) M dexamethasone prevents this effect. These results support the hypotheses that 1) treatment of psychotic Hex A deficient patients with amphiphilic antidepressants (such as imipramine) aggravates the patients' disease through depletion of their residual cellular Hex A, and 2) concomitant medication with dexamethasone may mitigate this drug-induced deleterious effect.
正常人类皮肤成纤维细胞在与10⁻⁴丙咪嗪孵育时会将其大部分己糖胺酶（Hex）分泌到培养基中，而预先用2.5×10⁻⁹ M地塞米松孵育可防止这种效应。这些结果支持以下假设：1）用两亲性抗抑郁药（如丙咪嗪）治疗精神病性己糖胺酶A缺乏患者会通过耗尽其残余细胞己糖胺酶A而加重患者病情，以及2）同时使用地塞米松可能减轻这种药物诱导的有害效应。
