光氧化还原诱导的芳基碘化物分子内 1,5-H 转移反应用于合成螺环γ-内酰胺。
Photoredox-Induced Intramolecular 1,5-H Transfer Reaction of Aryl Iodides for the Synthesis of Spirocyclic γ-Lactams.
机构信息
State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , PR China.
出版信息
Org Lett. 2018 Apr 20;20(8):2395-2398. doi: 10.1021/acs.orglett.8b00731. Epub 2018 Apr 3.
PMID:29613807
Abstract
This work develops a photocatalysis method for the synthesis of γ-spirolactams through a tandem intramolecular 1,5-HAT reaction-cyclization process. A variety of novel γ-spirolactams are prepared in good to excellent yields with this method. This transformation features mild reaction conditions and exceptional functional group tolerance. Additionally, γ-terpinene is applied to this transformation as a hydrogen atom donor for the first time.
摘要
本工作开发了一种通过串联分子内 1,5-HAT 反应-环化过程合成 γ-螺内酰胺的光催化方法。该方法可高效制备多种新型 γ-螺内酰胺。该转化具有反应条件温和和对官能团容忍性好的特点。此外，γ-松油烯首次被用作该转化中的氢原子供体。
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