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优化缺血性短暂性脑缺血发作急性期的二级预防。

Optimising secondary prevention in the acute period following a TIA of ischaemic origin.

作者信息

Heron Neil

机构信息

Department of General Practice and Primary Care, Queen's University, Belfast, UK.

Centre for Public Health Research, Queen's University, Belfast, UK.

出版信息

BMJ Open Sport Exerc Med. 2017 Jan 6;2(1):e000161. doi: 10.1136/bmjsem-2016-000161. eCollection 2016.

Abstract

BACKGROUND

Transient ischaemic attacks (TIAs) are highly prevalent conditions, with at least 46 000 people per year in the UK having a TIA for the first time. TIAs are a warning that the patient is at risk of further vascular events and the 90-day risk of vascular events following a TIA, excluding events within the first week after diagnosis when the risk is highest, can be as high as 18%. Immediate assessment of patients with TIA, either at accident and emergency, general practice and/or TIA clinics, is therefore required to address secondary prevention and prevent further vascular events.

DISCUSSION

This article addresses the need for optimising secondary prevention in the acute period following a TIA of ischaemic origin to reduce the risk of further vascular events as per recent Cochrane review advice and presents a novel project, Stroke Prevention Rehabilitation Intervention Trial of Exercise (SPRITE), to do this.

SUMMARY

One novel way to tackle vascular risk factors and promote secondary prevention in patients with TIA could be to adapt a cardiac rehabilitation programme for these patients. SPRITE, a feasibility and pilot study (ClinicalTrials.gov Identifier: NCT02712385) funded by the National Institute for Health Research, is attempting to adapt a home-based cardiac rehabilitation programme, 'The Healthy Brain Rehabilitation Manual', for use in the acute period following a TIA. The use of cardiac rehabilitation programmes post-TIA requires further research, particularly within the primary care setting.

摘要

背景

短暂性脑缺血发作(TIA)极为常见,在英国每年至少有46000人首次发作TIA。TIA是一种警示,提示患者有发生更多血管事件的风险,TIA后90天内发生血管事件的风险(不包括诊断后第一周内风险最高时发生的事件)可高达18%。因此,需要在事故与急救部门、全科医疗和/或TIA诊所对TIA患者进行即时评估,以进行二级预防并防止更多血管事件的发生。

讨论

本文根据最近的Cochrane系统评价建议,探讨了在缺血性TIA急性期优化二级预防以降低更多血管事件风险的必要性,并提出了一个新项目——运动性卒中预防康复干预试验(SPRITE)来实现这一目标。

总结

应对TIA患者血管危险因素并促进二级预防的一种新方法可能是为这些患者调整心脏康复计划。SPRITE是一项由英国国家卫生研究院资助的可行性和试点研究(ClinicalTrials.gov标识符:NCT02712385),正试图调整一项基于家庭的心脏康复计划《健康大脑康复手册》,以供TIA急性期使用。TIA后使用心脏康复计划需要进一步研究,尤其是在初级保健环境中。

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