Takahashi Yoshiko, Kudo Ryo, Tadokoro Ryosuke, Atsuta Yuji
of Zoology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto, Japan.
Int J Dev Biol. 2018;62(1-2-3):79-84. doi: 10.1387/ijdb.170290yt.
During embryogenesis, different tissues develop coordinately, and this coordination is often in harmony with body growth. Recent studies allow us to understand how this harmonious regulation is achieved at the levels of inter-cellular, inter-tissue, and tissue-body relationships. Here, we present an overview of recently revealed mechanisms by which axial growth (tail growth) drives a variety of morphogenetic events, with a focus on the coordinated progression between Wolffian (nephric) duct elongation and somitogenesis. We also discuss how we can relate this coordination to the events occurring during limb bud outgrowth, since the limb buds and tail bud are appendage anlagen acquired during vertebrate evolution, both of which undergo massive elongation/outgrowth.
在胚胎发生过程中，不同组织协同发育，这种协调通常与身体生长相协调。最近的研究使我们能够了解这种协调调节是如何在细胞间、组织间以及组织与身体关系层面实现的。在此，我们概述了最近揭示的机制，即轴向生长（尾部生长）如何驱动各种形态发生事件，重点关注中肾管伸长与体节形成之间的协调进展。我们还讨论了如何将这种协调与肢芽长出过程中发生的事件联系起来，因为肢芽和尾芽是脊椎动物进化过程中获得的附属器官原基，两者都会经历大量的伸长/长出。
