Wehkamp Ulrike, Weichenthal Michael, Egberts Friederike, Schwarz Thomas, Klapper Wolfram, Oschlies Ilske
a Department of Dermatology , University Hospital Schleswig-Holstein , Kiel , Germany.
b Department of Pathology, Hematopathology Section , University Hospital Schleswig-Holstein , Kiel , Germany.
Leuk Lymphoma. 2018 Dec;59(12):2871-2879. doi: 10.1080/10428194.2018.1452218. Epub 2018 Apr 4.
Most patients with mycosis fungoides (MF) remain in early disease stages but some progress to tumor stage. The individual course of the disease cannot be predicted. We wanted to assess the clinical and histological characteristics of the first available biopsy. An end-of-spectrum approach with two groups was used, comparing MF remaining long-term stable in T1a ('MF stable') and MF with later tumor development or present T3 stage ('MF tumor'). The clinical and histomorphological features of the initial skin biopsy were compared. Patients in the 'MF tumor' group presented initially with higher disease stages. The first biopsies of 'MF tumor' patients showed significantly higher infiltrate density and depth, more large cells and a higher proliferative index. In summary, long-term stable MF seems to differ in clinical and histopathological parameters from MF with T3 evolution/presence already at the time point of the initial biopsy. Our findings might indicate a predetermined biologic behavior.
大多数蕈样肉芽肿（MF）患者仍处于疾病早期阶段，但部分患者会进展至肿瘤期。该疾病的个体病程无法预测。我们旨在评估首次可获得活检的临床和组织学特征。采用了一种分两组的极端情况分析方法，比较长期处于T1a期稳定的MF（“MF稳定组”）和出现肿瘤进展或处于T3期的MF（“MF肿瘤组”）。对比了初始皮肤活检的临床和组织形态学特征。“MF肿瘤组”患者最初表现为更高的疾病分期。“MF肿瘤组”患者的首次活检显示浸润密度和深度显著更高，大细胞更多且增殖指数更高。总之，长期稳定的MF在临床和组织病理学参数方面似乎与在初次活检时就已出现T3进展/处于T3期的MF有所不同。我们的研究结果可能表明存在一种预先确定的生物学行为。
