College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Division of Pediatric Surgery, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
Nutr Clin Pract. 2018 Aug;33(4):545-552. doi: 10.1002/ncp.10083. Epub 2018 Apr 4.
This study examined clinical outcomes associated with the use of a gastroschisis-specific (GS) feeding advancement guideline.
We performed a retrospective study of all simple gastroschisis babies (N = 65) treated between June 2009June 2015. We compared patients treated on a postintestinal surgery guideline using either a 1-day (1D) or 3-day (3D) feeding advancement from August 2009-August 2013 with infants treated on a GS guideline from September 2013-June 2015.
Patients in the 2 groups were similar in sex, race, gestational age, weight, and comorbidities. Median time to full enteral nutrition (EN) was 11 days for the 1D group, 22 days for the 3D group, and 18 days for the GS group (P < .01). However, lengths of stay and estimated weight gain per day were similar among the groups. A total of 3 infants (10%) in the 1D group developed necrotizing enterocolitis compared with none in the 3D or GS groups. Control chart analysis showed reduced variation in median time to full EN in the GS group when compared with the 1D and 3D groups. Guideline adherence was significantly better with the GS guideline when compared with the 1D or 3D guidelines (94% vs 72% vs 90%; P < .01).
A GS protocol yielded reduced variation in median time to full EN, significant improvement in percent adherence to the guideline, and zero cases of necrotizing enterocolitis. Weight gain and lengths of stay were not adversely affected by slower feeds.
本研究考察了使用特定于腹裂(GS)喂养进阶指南的临床结果。
我们对 2009 年 6 月至 2015 年 6 月间接受治疗的所有单纯性腹裂婴儿(N=65)进行了回顾性研究。我们比较了 2009 年 8 月至 2013 年 8 月期间根据术后肠内喂养指南接受 1 天(1D)或 3 天(3D)喂养进阶的患者,与 2013 年 9 月至 2015 年 6 月期间根据 GS 指南接受治疗的婴儿。
两组患者的性别、种族、胎龄、体重和合并症均相似。第 1 组完全肠内营养(EN)的中位时间为 11 天,第 3 组为 22 天,GS 组为 18 天(P<.01)。然而,各组的住院时间和估计每天体重增加相似。第 1 组中有 3 名婴儿(10%)发生坏死性小肠结肠炎,而第 3 组和 GS 组均无。控制图分析显示,与 1D 组和 3D 组相比,GS 组完全 EN 的中位时间变化减少。与 1D 或 3D 指南相比,GS 指南的指南遵循率显著提高(94%比 72%比 90%;P<.01)。
GS 方案使完全 EN 的中位时间变化减少,显著提高了对指南的遵循率,且无坏死性小肠结肠炎病例。较慢的喂养速度不会对体重增加和住院时间产生不利影响。