Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Acta Paediatr. 2018 Oct;107(10):1722-1725. doi: 10.1111/apa.14354. Epub 2018 Apr 30.
Urinary N-terminal B-type natriuretic peptide NTproBNP levels are associated with the development of retinopathy of prematurity (ROP) in infants <30 weeks of gestation. The incidence of ROP in more mature infants who meet other ROP screening criteria is very low. We therefore aimed to test whether urinary NTproBNP predicted ROP development in these infants.
Prospective observational study in 151 UK infants ≥30 + 0 weeks of gestation but also <32 weeks of gestation and/or <1501 g, to test the hypothesis that urinary NTproBNP levels on day of life (DOL) 14 and 28 were able to predict ROP development.
Urinary NTproBNP concentrations on day 14 and day 28 of life did not differ between infants with and without ROP (medians 144 vs 128 mcg/mL, respectively, p = 0.86 on DOL 14 and medians 117 vs 94 mcg/mL, respectively, p = 0.64 on DOL28).
The association previously shown for infants <30 completed weeks between urinary NTproBNP and the development of ROP was not seen in more mature infants. Urinary NTproBNP does not appear helpful in rationalising direct ophthalmoscopic screening for ROP in more mature infants, and may suggest a difference in pathophysiology of ROP in this population.
尿 N 端脑利钠肽前体 NTproBNP 水平与<30 周胎龄早产儿视网膜病变（ROP）的发生有关。符合其他 ROP 筛查标准的更成熟婴儿的 ROP 发生率非常低。因此，我们旨在测试尿 NTproBNP 是否可以预测这些婴儿的 ROP 发展。
对 151 名英国婴儿进行前瞻性观察研究，胎龄≥30+0 周但<32 周且/或体重<1501g，以检验尿 NTproBNP 水平在第 14 天和第 28 天能否预测 ROP 发展的假设。
有 ROP 和无 ROP 的婴儿在第 14 天和第 28 天的尿 NTproBNP 浓度没有差异（第 14 天分别为 144 与 128mcg/mL，p=0.86；第 28 天分别为 117 与 94mcg/mL，p=0.64）。
先前在<30 周完全胎龄的婴儿中观察到的尿 NTproBNP 与 ROP 发生之间的关联，在更成熟的婴儿中并未出现。尿 NTproBNP 似乎无助于合理化对更成熟婴儿的 ROP 直接眼底镜筛查，并且可能表明该人群 ROP 的病理生理学存在差异。
