伪激酶双重奏

A Pseudo-Kinase Double Act.

机构信息

Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium, Max-von-Laue-Str. 15, D-60438 Frankfurt am Main, Germany.

出版信息

Structure. 2018 Apr 3;26(4):527-528. doi: 10.1016/j.str.2018.03.008.

DOI:10.1016/j.str.2018.03.008

PMID:29617648

Abstract

Pragmin is a catalytically inactive pseudo-kinase that is important in regulating cellular growth and adhesion. In this issue of Structure, Lecointre et al. (2018) present the structure of Pragmin, illustrating a dimerization domain flanking its pseudo-kinase domain that is important for Pragmin-mediated activation of the non-receptor tyrosine kinase CSK.

摘要

Pragmin 是一种无催化活性的拟激酶，对于调节细胞生长和黏附非常重要。在本期的《结构》杂志中，Lecointre 等人（2018）呈现了 Pragmin 的结构，阐明了侧翼其拟激酶结构域的二聚化结构域对于 Pragmin 介导的非受体酪氨酸激酶 CSK 的激活非常重要。