Hum Reprod. 2018 May 1;33(5):770-776. doi: 10.1093/humrep/dey056.
Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.
许多已发表的医学研究显然存在缺陷，无法复制和/或具有有限或没有实用性。本文概述了当前生物医学研究的现状，确定了与常见研究设计相关的问题，并考虑了潜在的解决方案。本文从固有局限性和改进其实施、分析和报告的潜在方法的角度讨论了随机临床试验、观察性研究、系统评价和荟萃分析。目前对统计显著性的强调需要被合理的设计、透明度和与明确提高临床研究质量和实用性的意愿共享数据所取代。
