Fatima Syeda Anum, Baig Sadia Ghousia, Hasan Muhammad Mohtasheemul, Ahmed Salman, Salma -
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Pak J Pharm Sci. 2018 Mar;31(2):581-585.
Macrotyloma uniflorum commonly known as horse gram or kulthi bean is grown as a pulse for livestock and human consumption. The beans contain about 1.3% fat, 18% protein, 15% carbohydrate along with vitamins and minerals. In traditional medicine it is used as antihyperglycemic, antioxidant, antihypertensive and diuretic. Other important medicinal uses include treatment of renal stones, obesity, piles, oedema and fever. The present study evaluated analgesic (by acetic acid induced writhing, hot plate and tail flick tests in mice) and anti-inflammatory (carrageenan induced paw edema in rats) activities of Macrotyloma uniflorum fixed oil (MUFO). Four groups were included in study: Group-I: Normal Saline Control (2ml/kg), Group-II: MUFO (2ml/kg), Group-III: MUFO (4ml/kg), and Group-IV: Standard Acetyl salicylic acid (ASA 300mg/kg). All results were significant however delayed onset of action was observed in tail flick and paw edema tests. Acute oral toxicity of the oil was also checked in mice and was found safe upto 4ml/kg dose, as no signs of toxicity and mortality were observed. It is concluded that Macrotyloma uniflorum fixed oil may possess analgesic and anti-inflammatory activity which can be related with a peripheral mechanism of action.
单花大翼豆通常被称为马豆或库尔蒂豆，作为一种豆类作物种植，供牲畜和人类食用。这种豆子含有约1.3%的脂肪、18%的蛋白质、15%的碳水化合物以及维生素和矿物质。在传统医学中，它被用作抗高血糖、抗氧化、抗高血压和利尿剂。其他重要的药用用途包括治疗肾结石、肥胖、痔疮、水肿和发烧。本研究评估了单花大翼豆固定油（MUFO）的镇痛作用（通过小鼠醋酸诱导扭体、热板和甩尾试验）和抗炎作用（大鼠角叉菜胶诱导的足肿胀试验）。研究包括四组：第一组：生理盐水对照组（2ml/kg），第二组：MUFO（2ml/kg），第三组：MUFO（4ml/kg），第四组：标准乙酰水杨酸（ASA 300mg/kg）。所有结果均具有显著性，但在甩尾和足肿胀试验中观察到起效延迟。还对该油在小鼠中的急性口服毒性进行了检查，发现剂量高达4ml/kg时是安全的，因为未观察到毒性和死亡迹象。得出的结论是，单花大翼豆固定油可能具有镇痛和抗炎活性，这可能与外周作用机制有关。
