儿童急性淋巴细胞白血病的核型与免疫表型的相关性

Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia.

作者信息

Pui C H, Williams D L, Roberson P K, Raimondi S C, Behm F G, Lewis S H, Rivera G K, Kalwinsky D K, Abromowitch M, Crist W M

机构信息

Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38101.

出版信息

J Clin Oncol. 1988 Jan;6(1):56-61. doi: 10.1200/JCO.1988.6.1.56.

DOI:10.1200/JCO.1988.6.1.56

PMID:2961852

Abstract

To correlate leukemic cell karyotype with immunophenotype, we studied 364 children with acute lymphoblastic leukemia (ALL). A prognostically favorable cytogenetic feature, hyperdiploidy greater than 50 chromosomes, was found in 33% of cases classified as common ALL antigen positive (CALLA+) early pre-B (common) ALL, in contrast to 18% of pre-B cases (P = .012), 5% of T cell cases (P less than .001), and none of the B cell cases (P less than .001) or cases of CALLA negative (CALLA-) early pre-B ALL (P = .002). The frequency of translocations, an adverse cytogenetic feature, was significantly lower in CALLA+ early pre-B ALL cases (35%) than in B cell (100%; P less than .0001), pre-B (59%; P less than .001), or CALLA- early pre-B (62%; P = .016) cases. Thus, patterns of chromosomal change differ widely among the major immunophenotypic groups of ALL and may account for reported differences in responsiveness to treatment.

摘要

为了将白血病细胞的核型与免疫表型相关联，我们研究了364例急性淋巴细胞白血病（ALL）患儿。在分类为普通ALL抗原阳性（CALLA+）的早期前B（普通）ALL病例中，33%发现了一种预后良好的细胞遗传学特征，即超二倍体大于50条染色体，相比之下，前B病例中这一比例为18%（P = 0.012），T细胞病例中为5%（P小于0.001），B细胞病例及CALLA阴性（CALLA-）早期前B ALL病例中均未发现（P小于0.001）（P = 0.002）。易位是一种不良细胞遗传学特征，其在CALLA+早期前B ALL病例中的发生率（35%）显著低于B细胞病例（100%；P小于0.0001）、前B病例（59%；P小于0.001）或CALLA-早期前B病例（62%；P = 0.016）。因此，ALL主要免疫表型组之间的染色体变化模式差异很大，这可能解释了报道的治疗反应差异。