Wong K Y, Jones M M, Srivastava A K, Gruppo R A
Division of Hematology-Oncology, Children's Hospital Medical Center, Cincinnati, OH 45229.
J Pediatr. 1988 Jan;112(1):18-22. doi: 10.1016/s0022-3476(88)80112-4.
Two infants with Down syndrome had transient myeloproliferative disorder (TMD) during the neonatal period and subsequently acute nonlymphoblastic leukemia (ANLL). Histochemically, the blast cells in TMD were indistinguishable from those in ANLL. Only the constitutional chromosome (trisomy 21) was found in TMD, whereas new cytogenetic abnormalities emerged in ANLL. A mixed growth pattern in stem cell cultures during TMD suggested the existence of an abnormal clone that might be responsible for the evolution into ANLL at a later date. Serial cytogenetic studies and culture studies of peripheral blood cells may help to understand the pathophysiology and risk of ANLL in patients with TMD.
两名唐氏综合征婴儿在新生儿期患有短暂性骨髓增殖性疾病（TMD），随后发展为急性非淋巴细胞白血病（ANLL）。组织化学检查显示，TMD中的原始细胞与ANLL中的无法区分。TMD中仅发现了先天性染色体（21三体），而ANLL中出现了新的细胞遗传学异常。TMD期间干细胞培养的混合生长模式提示存在异常克隆，可能是导致日后发展为ANLL的原因。对外周血细胞进行连续的细胞遗传学研究和培养研究，可能有助于了解TMD患者ANLL的病理生理学和风险。
