Saitoh Yuu, Gotoh Moritaka, Yoshizawa Seiichiro, Akahane Daigo, Fujimoto Hiroaki, Ito Yoshikazu, Ohyashiki Kazuma
Department of Hematology, Tokyo Medical University.
Rinsho Ketsueki. 2018;59(3):300-304. doi: 10.11406/rinketsu.59.300.
A-46-year-old man was diagnosed with peripheral T cell lymphoma, not otherwise specified. He achieved a complete remission after pirarubicin, cyclophosphamide, vincristine, and prednisolone (THP-COP) therapy and successful autologous peripheral blood stem-cell transplantation (AutoSCT). However, 6 months post AutoSCT, he complained of fever. Chest computed tomography of the patient displayed bilateral interstitial pneumonitis. Human herpesvirus-6 (HHV-6) DNA was detected in his bronchoalveolar lavage fluid. Therefore, the patient was confirmed for HHV-6 pneumonitis. The treatment with foscarnet was effective, and no relapse was noticed in the patient. Besides, we have experienced pneumonitis of unknown origin in some patients after autologous or allogeneic stem-cell transplantations. Moreover, most of the above patients were clinically diagnosed using serum or plasma markers. Therefore, examining respiratory symptoms after AutoSCT would enable a more accurate diagnosis as well as treatment of patients with HHV-6 pneumonitis.
一名46岁男性被诊断为外周T细胞淋巴瘤，其他类型未另行指定。他在接受吡柔比星、环磷酰胺、长春新碱和泼尼松龙（THP-COP）治疗以及成功进行自体外周血干细胞移植（AutoSCT）后实现了完全缓解。然而，AutoSCT后6个月，他出现发热症状。患者的胸部计算机断层扫描显示双侧间质性肺炎。在他的支气管肺泡灌洗液中检测到人类疱疹病毒6型（HHV-6）DNA。因此，该患者被确诊为HHV-6肺炎。膦甲酸钠治疗有效，患者未出现复发。此外，我们在一些自体或异基因干细胞移植后的患者中遇到过不明原因的肺炎。而且，上述大多数患者是通过血清或血浆标志物进行临床诊断的。因此，检查AutoSCT后的呼吸道症状将有助于更准确地诊断和治疗HHV-6肺炎患者。
