基于噬菌体展示的策略用于从头创建无二硫键约束和无异构体的双环肽亲和试剂。
A phage display-based strategy for the de novo creation of disulfide-constrained and isomer-free bicyclic peptide affinity reagents.
机构信息
Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, P. R. China.
出版信息
Chem Commun (Camb). 2018 Apr 17;54(32):4029-4032. doi: 10.1039/c7cc09142g.
Bicyclic peptides have been attractive scaffolds for developing high affinity reagents for biomacromolecules. Here we report a general phage-screening strategy for the development of bicyclic peptide ligands constrained with isomerically-forbidden disulfide bridges without elaborate chemical modifications and recourses to genetic code reprogramming.
双环肽一直是开发生物大分子高亲和力试剂的有吸引力的支架。在这里，我们报告了一种通用的噬菌体筛选策略，用于开发具有异构禁阻二硫键约束的双环肽配体，而无需进行精心的化学修饰和遗传密码重编程。
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