轻度头部创伤中 copeptin 水平的升高并不能预测脑损伤的严重程度和预后。
The increase in copeptin levels in mild head trauma does not predict the severity and the outcome of brain damage.
作者信息
Castello Luigi M, Salmi Livia, Zanotti Isabella, Gardino Clara A, Baldrighi Marco, Settanni Fabio, Avanzi Gian C
机构信息
Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli, 17. 28100 - Novara, Italy.
AOU Maggiore della Carità, Corso Mazzini, 18. 28100 - Novara, Italy.
出版信息
Biomark Med. 2018 Jun;12(6):555-563. doi: 10.2217/bmm-2018-0041. Epub 2018 Apr 5.
AIM
To investigate the copeptin prognostic role in mild head trauma.
METHODS
We enrolled 105 adult patients who entered the emergency room because of recent mild head trauma; we evaluated: clinical picture, imaging and laboratory data (including copeptin).
RESULTS
Copeptin resulted higher in mild head trauma patients compared with controls: 29.89 pmol/l versus 7.05 pmol/l (p = 0.0008). Copeptin failed in identifying patients with or without brain lesions detected by CT scan, and patients with or without adverse events during the 30 days follow-up.
CONCLUSION
We confirmed that mild head trauma patients have a significantly higher copeptin plasma levels compared with controls. Nevertheless, we did not observe a significant role for copeptin in traumatic brain injury patients regarding brain damage and outcome.
目的
探讨 copeptin 在轻度颅脑外伤中的预后作用。
方法
我们纳入了 105 例因近期轻度颅脑外伤而进入急诊室的成年患者；我们评估了：临床表现、影像学和实验室数据（包括 copeptin）。
结果
与对照组相比，轻度颅脑外伤患者的 copeptin 水平更高：29.89 pmol/l 对 7.05 pmol/l（p = 0.0008）。Copeptin 无法识别出 CT 扫描检测到有或无脑损伤的患者，以及在 30 天随访期间有或无不良事件的患者。
结论
我们证实，与对照组相比，轻度颅脑外伤患者的 copeptin 血浆水平显著更高。然而，我们未观察到 copeptin 在创伤性脑损伤患者的脑损伤和预后方面发挥显著作用。
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