Castello Luigi M, Salmi Livia, Zanotti Isabella, Gardino Clara A, Baldrighi Marco, Settanni Fabio, Avanzi Gian C
Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli, 17. 28100 - Novara, Italy.
AOU Maggiore della Carità, Corso Mazzini, 18. 28100 - Novara, Italy.
Biomark Med. 2018 Jun;12(6):555-563. doi: 10.2217/bmm-2018-0041. Epub 2018 Apr 5.
To investigate the copeptin prognostic role in mild head trauma.
We enrolled 105 adult patients who entered the emergency room because of recent mild head trauma; we evaluated: clinical picture, imaging and laboratory data (including copeptin).
Copeptin resulted higher in mild head trauma patients compared with controls: 29.89 pmol/l versus 7.05 pmol/l (p = 0.0008). Copeptin failed in identifying patients with or without brain lesions detected by CT scan, and patients with or without adverse events during the 30 days follow-up.
We confirmed that mild head trauma patients have a significantly higher copeptin plasma levels compared with controls. Nevertheless, we did not observe a significant role for copeptin in traumatic brain injury patients regarding brain damage and outcome.
探讨 copeptin 在轻度颅脑外伤中的预后作用。
我们纳入了 105 例因近期轻度颅脑外伤而进入急诊室的成年患者；我们评估了：临床表现、影像学和实验室数据（包括 copeptin）。
与对照组相比，轻度颅脑外伤患者的 copeptin 水平更高：29.89 pmol/l 对 7.05 pmol/l（p = 0.0008）。Copeptin 无法识别出 CT 扫描检测到有或无脑损伤的患者，以及在 30 天随访期间有或无不良事件的患者。
我们证实，与对照组相比，轻度颅脑外伤患者的 copeptin 血浆水平显著更高。然而，我们未观察到 copeptin 在创伤性脑损伤患者的脑损伤和预后方面发挥显著作用。
