Amornchaicharoensuk Yupaporn
Southeast Asian J Trop Med Public Health. 2016 Sep;47(5):976-82.
Medical records of children less than 15-years of age admitted to hospital for urinary tract infection (UTI) from January 2010 to December 2014 were reviewed. Among 100 children (59% males and 41% females) with upper UTI, the most common pathogen (88%) was Escherichia coli, of which 69% were nonextended spectrum beta-lactamase (ESBL) and 19 % ESBL producers. Resistance to ampicillin and trimethoprim/sulfamethoxazole was 90% and 60%, respectively. All ESBL-producing E. coli were resistant to ampicillin and third generation cephalosporins (cefotaxime and ceftriaxone), while 87% and 1.5% of non ESBL-producing E. coli were resistant to ampicillin and the two third generation cephalosporins, respectively. These data highlight the high prevalence of ESBL-producing E. coli in pediatric UTI and the potential problem in treating such infections.
对2010年1月至2014年12月因尿路感染（UTI）住院的15岁以下儿童的病历进行了回顾。在100例上尿路感染患儿中（59%为男性，41%为女性），最常见的病原体（88%）是大肠杆菌，其中69%为非超广谱β-内酰胺酶（ESBL）菌株，19%为ESBL产生菌。对氨苄西林和甲氧苄啶/磺胺甲恶唑的耐药率分别为90%和60%。所有产ESBL的大肠杆菌对氨苄西林和第三代头孢菌素（头孢噻肟和头孢曲松）均耐药，而非产ESBL的大肠杆菌分别有87%和1.5%对氨苄西林和这两种第三代头孢菌素耐药。这些数据突出了产ESBL大肠杆菌在儿童UTI中的高流行率以及治疗此类感染的潜在问题。
